Conformational Heterogeneity Determined by Folding and Oligomer Assembly Routes of the Interferon Response Inhibitor NS1 Protein, Unique to Human Respiratory Syncytial Virus

The nonstructural NS1 protein is an essential virulence factor of the human respiratory syncytial virus, with a predominant role in the inhibition of the host antiviral innate immune response. This inhibition is mediated by multiple protein-protein interactions and involves the formation of large ol...

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Detalles Bibliográficos
Autores principales:	Pretel, E., Sánchez, I.E., Fassolari, M., Chemes, L.B., De Prat-Gay, G.
Formato:	JOUR
Materias:	Antibiotics Conformations Glycoproteins Immune system Life cycle Monomers Oligomers Polymerization Viruses Conformational heterogeneity Innate immune response Macromolecular crowding Protein concentrations Protein-protein interactions Respiratory syncytial virus Subcellular localizations Transition state ensembles Proteins amyloid monomer nonstructural protein 1 oligomer interferon protein binding virus protein Article beta sheet binding affinity cellular distribution controlled study half life time Human respiratory syncytial virus isomerization macromolecular crowding nonhuman observed rate constant oligomerization polymerization priority journal protein assembly protein conformation protein folding protein metabolism protein protein interaction protein quaternary structure protein secondary structure protein unfolding temperature chemistry enzyme specificity human kinetics metabolism physiology protein multimerization protein refolding solubility species difference Humans Interferons Kinetics Protein Binding Protein Folding Protein Multimerization Protein Refolding Protein Structure, Quaternary Protein Unfolding Respiratory Syncytial Virus, Human Solubility Species Specificity Substrate Specificity Temperature Viral Nonstructural Proteins
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00062960_v54_n33_p5136_Pretel
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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