P38γ activation triggers dynamical changes in allosteric docking sites

Mitogen-activated protein kinases (MAPKs) are serine-threonine kinases that participate in signal transduction pathways. p38 MAPKs have four isoforms (p38β, p38β, p38γ, and p38δ) which are involved in multiple cellular functions such as proliferation, differentiation, survival, and migration. MAPK k...

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Detalles Bibliográficos
Autores principales: Rodriguez Limardo, R.G., Ferreiro, D.N., Roitberg, A.E., Marti, M.A., Turjanski, A.G.
Formato: JOUR
Materias:
Activation loops
Active site
ATP binding
Bound state
Catalytic activity
Conformational change
Correlated dynamics
Docking sites
Dynamical fluctuations
Isoforms
Key factors
MD simulation
Mitogen activated protein kinase
Molecular dynamics techniques
Multiple cellular functions
Protein domains
Protein dynamics
Protein-protein interactions
Signal transduction pathways
Signaling networks
Threonine kinase
Two domains
Amino acids
Binding energy
Docking
Dynamics
Enzymes
Molecular dynamics
Phosphorylation
Plasticity
Signal transduction
Signaling
Catalyst activity
adenosine triphosphate
mitogen activated protein kinase p38
mitogen activated protein kinase p38 gamma
unclassified drug
article
binding site
conformational transition
enzyme activation
enzyme active site
enzyme conformation
enzyme phosphorylation
molecular dynamics
motion
priority journal
protein domain
protein protein interaction
simulation
Adenosine Triphosphate
Allosteric Regulation
Enzyme Activation
Mitogen-Activated Protein Kinase 12
Molecular Dynamics Simulation
Movement
Protein Structure, Secondary
Protein Structure, Tertiary
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00062960_v50_n8_p1384_RodriguezLimardo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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