Critical role of the solvent environment in galectin-1 binding to the disaccharide lactose

Galectin-1 (Gal-1), a member of a family of evolutionarily conserved glycan-binding proteins, binds specifically to poly-N-acetyllactosamine-enriched glycoconjugates. Through interactions with these glycoconjugates, this protein modulates inflammatory responses and contributes to tumor progression a...

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Detalles Bibliográficos
Autores principales:	Di Lella, S., Ma, L., Díaz Ricci, J.C., Rabinovich, G.A., Asher, S.A., Álvarez, R.M.S.
Formato:	JOUR
Materias:	Binding proteins Carbohydrate ligands Carbohydrate-recognition domains Disaccharide lactose Galectin-1 Glycoconjugates Immune cells Inflammatory response Ligand bindings Molecular dynamic simulations Physico-chemical properties Radial distribution functions Role of waters Solvent environments Solvent reorganizations Structural changes Synthetic inhibitors Tumor progressions Uv-raman spectrum Uv-resonance raman spectroscopies Amino acids Biochemistry Ligands Molecular dynamics Organic compounds Polysaccharides Raman scattering Raman spectroscopy Sugars Distribution functions carbohydrate disaccharide galectin 1 glycan lactose solvent tryptophan LGALS1 protein, human water article genetic conservation homeostasis human immunocompetent cell inflammation ligand binding molecular dynamics nonhuman physical chemistry priority journal protein carbohydrate interaction protein family Raman spectrometry tumor growth chemical model chemistry comparative study computer simulation metabolism protein binding thermodynamics X ray crystallography Computer Simulation Crystallography, X-Ray Galectin 1 Humans Lactose Models, Chemical Protein Binding Solvents Spectrum Analysis, Raman Thermodynamics Water
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00062960_v48_n4_p786_DiLella
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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