α-RgIA: A novel conotoxin that specifically and potently blocks the α9α10 nAChR

The α9 and α10 nicotinic acetylcholine receptor (nAChR) subunits assemble to form the α9α10 nAChR subtype. This receptor is believed to mediate cholinergic synaptic transmission between efferent olivocochlear fibers and the hair cells of the cochlea. In addition α9 and/or α10 expression has been des...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Ellison, M., Haberlandt, C., Gomez-Casati, M.E., Watkins, M., Elgoyhen, A.B., McIntosh, J.M., Olivera, B.M.
Formato: JOUR
Materias:
Amino acids
Biochemistry
Neurology
Skin
Tissue
Conotoxin
Dorsal root ganglion neurons
Lymphocytes
Nicotinic acetylcholine receptor (nAChR)
Cells
alpha conotoxin RgIA
alpha10 nicotinic receptor
alpha9 alpha10 nicotinic receptor
alpha9 nicotinic receptor
amino acid
conotoxin
nicotinic receptor
nicotinic receptor blocking agent
receptor subtype
receptor subunit
unclassified drug
animal cell
animal tissue
article
carboxy terminal sequence
cholinergic transmission
cochlea
controlled study
Conus regius
efferent nerve
hair cell
hypophysis pars tuberalis
keratinocyte
lymphocyte
nonhuman
priority journal
protein assembly
protein expression
rat
receptor blocking
snail
spinal ganglion
toxin structure
Animals
Base Sequence
Cloning, Molecular
Conotoxins
Gene Expression Regulation
Hair Cells, Inner
Molecular Sequence Data
Oocytes
Polymerase Chain Reaction
Protein Subunits
Rats
Rats, Sprague-Dawley
Receptors, Nicotinic
Species Specificity
Xenopus
Animalia
Gastropoda
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00062960_v45_n5_p1511_Ellison
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Ejemplares similares

Ejemplares similares