Effect of tamoxifen on the sphingolipid biosynthetic pathway in the different intraerythrocytic stages of the apicomplexa Plasmodium falciparum

Parasites of the genus Plasmodium responsible for Malaria are obligate intracellular pathogens residing in mammalian red blood cells, hepatocytes, or mosquito midgut epithelial cells. Regarding that detailed knowledge on the sphingolipid biosynthetic pathway of the apicomplexan protozoan parasites i...

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Detalles Bibliográficos
Autores principales: Piñero, T.A., Landoni, M., Duschak, V.G., Katzin, A.M., Couto, A.S.
Formato: JOUR
Materias:
Glucosylceramide synthase
Glycosphingolipids
Plasmodium falciparum
Tamoxifen
ceramide glucosyltransferase
glycosphingolipid
phosphatidylinositol
sphingolipid
sphingomyelin
sphingomyelin synthase
tamoxifen
unclassified drug
inositolphosphoceramides
Apicomplexa
Article
controlled study
drug effect
enzyme inhibition
high performance liquid chromatography
life cycle stage
lipid storage
lipogenesis
matrix assisted laser desorption ionization time of flight mass spectrometry
nonhuman
priority journal
reversed phase liquid chromatography
schizont
sphingolipid metabolism
thin layer chromatography
trophozoite
biosynthesis
drug effects
erythrocyte
mass spectrometry
metabolism
parasitology
protozoal infection
Biosynthetic Pathways
Chromatography, Reverse-Phase
Erythrocytes
Life Cycle Stages
Mass Spectrometry
Phosphatidylinositols
Protozoan Infections
Sphingolipids
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0006291X_v497_n4_p1082_Pinero
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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