Membrane localization of Junín virus glycoproteins requires cholesterol and cholesterol rich membranes

Arenavirus morphogenesis and budding occurs at cellular plasma membrane; however, the nature of membrane assembly sites remains poorly understood. In this study we examined the effect of different cholesterol-lowering agents on Junín virus (JUNV) multiplication. We found that cholesterol cell deplet...

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Detalles Bibliográficos
Autores principales: Cordo, S.M., Valko, A., Martinez, G.M., Candurra, N.A.
Formato: JOUR
Materias:
Cholesterol
Junín virus
Membrane rafts
beta cyclodextrin
cholesterol
glycoprotein
triton x 100
virus glycoprotein
virus protein
animal cell
article
controlled study
Junin virus
nonhuman
priority journal
protein localization
virus release
Animals
Anticholesteremic Agents
Cell Membrane
Cercopithecus aethiops
Dogs
Madin Darby Canine Kidney Cells
Membrane Glycoproteins
Vero Cells
Viral Envelope Proteins
Virus Replication
Arenavirus
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0006291X_v430_n3_p912_Cordo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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