Sterol analogues with diamide side chains interfere with the intracellular localization of viral glycoproteins

The need to develop novel antiviral agents encouraged us to assess the antiviral activity of synthetic sterol analogues with a diamide side chains. Cytotoxicity and antiviral activity of a family of azasterol previously synthesized was evaluated against herpes simplex virus 1 (HSV-1) (KOS and B2006)...

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Detalles Bibliográficos
Autores principales:	Dávola, M.E., Alonso, F., Cabrera, G.M., Ramírez, J.A., Barquero, A.A.
Formato:	JOUR
Materias:	Antiviral Azasterol Glycoprotein transport HSV-1 Ugi reaction VSV azacosterol diamide glycoprotein D n [(tert butylcarbamoyl)methyl] n (2 chlorophenyl) 3beta hydroxyandrost 5 ene 17beta carboxamide n [(tert butylcarbamoyl)methyl] n (2 ethyl 6 methylphenyl) 3beta hydroxyandrost 5 ene 17beta carboxamide n [(tert butylcarbamoyl)methyl] n (2 fluorophenyl) 3beta hydroxyandrost 5 ene 17beta carboxamide n [(tert butylcarbamoyl)methyl] n (3 trifluorophenyl) 3beta hydroxyandrost 5 ene 17beta carboxamide n [(tert butylcarbamoyl)methyl] n (3,4 dichlorophenyl) 3beta hydroxyandrost 5 ene 17beta carboxamide n [(tert butylcarbamoyl)methyl] n (4 fluorophenyl) 3beta hydroxyandrost 5 ene 17beta carboxamide n [(tert butylcarbamoyl)methyl] n (4 methoxyphenyl) 3beta hydroxyandrost 5 ene 17beta carboxamide n [(tert butylcarbamoyl)methyl] n (4 methylphenyl) 3beta hydroxyandrost 5 ene 17beta carboxamide unclassified drug virus glycoprotein animal cell antiviral activity article chemical reaction drug synthesis fluorescence analysis Herpes simplex virus 1 nonhuman priority journal protein localization virogenesis virus inhibition Antiviral Agents Diamide Herpesvirus 1, Human Humans Intracellular Space Sterols Viral Envelope Proteins Virus Replication Human herpesvirus 1 Vesicular stomatitis virus
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_0006291X_v427_n1_p107_Davola
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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