Effect of trehalose on the interaction of Alzheimer's Aβ-peptide and anionic lipid monolayers

The interaction of amyloid β-peptide (Aβ) with cell membranes is believed to play a central role in the pathogenesis of Alzheimer's disease. In particular, recent experimental evidence indicates that bilayer and monolayer membranes accelerate the aggregation and amyloid fibril formation rate of...

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Detalles Bibliográficos
Autores principales: Izmitli, A., Schebor, C., McGovern, M.P., Reddy, A.S., Abbott, N.L., De Pablo, J.J.
Formato: JOUR
Materias:
Alzheimer's disease
Amyloid beta peptide
Membrane
Monolayer
Trehalose
amyloid beta protein
lipid
trehalose
alpha helix
Alzheimer disease
animal cell
animal experiment
aqueous solution
article
cell membrane
controlled study
enzyme kinetics
isotherm
Langmuir Blodgett film
lipid monolayer
mouse
nonhuman
priority journal
protein conformation
protein function
protein interaction
protein structure
thermodynamics
water temperature
Alzheimer Disease
Amyloid beta-Peptides
Animals
Anions
Computer Simulation
Humans
Lipid Bilayers
Mice
Models, Molecular
Molecular Conformation
Peptides
Phosphatidylglycerols
Temperature
Time Factors
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00052736_v1808_n1_p26_Izmitli
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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