Exploring the molecular basis of human manganese superoxide dismutase inactivation mediated by tyrosine 34 nitration

Manganese Superoxide Dismutase (MnSOD) is an essential mitochondrial antioxidant enzyme that protects organisms against oxidative damage, dismutating superoxide radical (O2-) into H2O2 and O2. The active site of the protein presents a Mn ion in a distorted trigonal-bipyramidal environment, coordinat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Moreno, D.M., Martí, M.A., De Biase, P.M., Estrin, D.A., Demicheli, V., Radi, R., Boechi, L.
Formato:	JOUR
Materias:	Enzyme inactivation Free energy Ligand migration Manganese superoxide dismutase MnSOD Molecular dynamics MSMD Multiple steered molecular dynamics Tyrosine nitration 3 nitrotyrosine manganese superoxide dismutase superoxide article computer simulation enzyme active site enzyme inactivation nitration priority journal protein function proton transport Catalytic Domain Enzyme Activation Humans Molecular Dynamics Simulation Mutation Nitro Compounds Superoxide Dismutase Superoxides Thermodynamics Tyrosine
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00039861_v507_n2_p304_Moreno
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Ejemplares similares

Exploring the molecular basis of human manganese superoxide dismutase inactivation mediated by tyrosine 34 nitration
por: Martí, Marcelo Adrián, et al.
Publicado: (2011)

Mechanism of the Reaction of Human Manganese Superoxide Dismutase with Peroxynitrite: Nitration of Critical Tyrosine 34
por: Demicheli, V., et al.

Mechanism of the Reaction of Human Manganese Superoxide Dismutase with Peroxynitrite: Nitration of Critical Tyrosine 34
por: Jara, Gabriel Ernesto, et al.
Publicado: (2016)

Structural and molecular basis of the peroxynitrite-mediated nitration and inactivation of trypanosoma cruzi iron-superoxide dismutases (fe-sods) a and b : Disparate susceptibilities due to the repair of tyr35 radical by cys83 in fe-sodb through intramolecular electron transfer
por: Martinez, A., et al.

Structural and molecular basis of the peroxynitrite-mediated nitration and inactivation of trypanosoma cruzi iron-superoxide dismutases (fe-sods) a and b : Disparate susceptibilities due to the repair of tyr35 radical by cys83 in fe-sodb through intramolecular electron transfer
por: Petruk, Ariel Alcides, et al.
Publicado: (2014)

Molecular relaxation and metalloenzyme active site modeling
por: Scherlis, D.A., et al.

Molecular relaxation and metalloenzyme active site modeling
por: Martí, Marcelo Adrián, et al.
Publicado: (2002)

Nitric oxide induces specific isoforms of antioxidant enzymes in soybean leaves subjected to enhanced ultraviolet - B radiation

The distinctive roles played by the superoxide dismutases of the extremophile Acinetobacter sp. Ver3
por: Steimbrüch, Bruno A., et al.
Publicado: (2022)

Desempenho bioquímico de plântulas de feijão sob restrição hídrica no início do desenvolvimento
por: Oliveira Novais Araújo, Bruno, et al.
Publicado: (2021)

Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.0216733 mM
por: Kembro, Jackelyn Melissa, et al.
Publicado: (2020)

Periodic oscillations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.013 mM
por: Kembro, Jackeline Melissa, et al.
Publicado: (2020)

Is Cardiac Hypertrophy in Spontaneously Hypertensive Rats the Cause or the Consequence of Oxidative Stress?
por: Álvarez, María Cecilia, et al.
Publicado: (2008)

The inhibitory effect of vanadium oxoanions on the activity of copper-zinc superoxide dismutase
por: Apella, María Cristina, et al.
Publicado: (1988)

Copper-zinc superoxide dismutase activity in red blood cells in probable Alzheimer's patients and their first-degree relatives
Publicado: (1994)

Copper-zinc superoxide dismutase activity in red blood cells in probable Alzheimer's patients and their first-degree relatives
por: Serra, J.A., et al.

Alterations of the antioxidant enzyme activities are not general characteristics of the colonization process by arbuscular mycorrhizal fungi
por: Rodríguez, Yakelin, et al.
Publicado: (2012)

Comparison of the determination of superoxide dismutase and antioxidant capacity in neurological patients using two different procedures
por: Serra, J.A., et al.

Photodynamic therapy of activated and resting lymphocytes and its antioxidant adaptive response
por: Casas, A., et al.

Comparison of the determination of superoxide dismutase and antioxidant capacity in neurological patients using two different procedures
por: Marschoff, Enrique R.
Publicado: (2000)

Dimerization, redox properties and antioxidant activity of two manganese(III) complexes of difluoro- and dichloro-substituted Schiff-base ligands
por: Doctorovich, Fabio Ariel
Publicado: (2017)

Dimerization, redox properties and antioxidant activity of two manganese(III) complexes of difluoro- and dichloro-substituted Schiff-base ligands
por: Palopoli, C., et al.

Photodynamic therapy of activated and resting lymphocytes and its antioxidant adaptive response
Publicado: (2002)

Resonance Raman study of the superoxide reductase from Archaeoglobus fulgidus, E12 mutants and a 'natural variant'
por: Todorovic, S., et al.

Resonance Raman study of the superoxide reductase from Archaeoglobus fulgidus, E12 mutants and a 'natural variant'
por: Murgida, Daniel Horacio
Publicado: (2009)

Manganese superoxide dismutase gene expression is induced by Nanog and Oct4, essential pluripotent stem cells' transcription factors
por: Solari, C., et al.

Oxidative stress in Vero cells infected with vesicular stomatitis virus
por: Riva, D.A., et al.

Manganese superoxide dismutase gene expression is induced by Nanog and Oct4, essential pluripotent stem cells' transcription factors
por: Cosentino, María Soledad, et al.
Publicado: (2015)

The antioxidant enzymatic blood profile in Alzheimer's and vascular diseases. Their association and a possible assay to differentiate demented subjects and controls
por: Famulari, A.L., et al.

Oxidative stress in Vero cells infected with vesicular stomatitis virus
Publicado: (2006)

The antioxidant enzymatic blood profile in Alzheimer's and vascular diseases. Their association and a possible assay to differentiate demented subjects and controls
Publicado: (1996)

Differential effects of paraquat on oxidative stress parameters and polyamine levels in two freshwater invertebrates
por: Cochón, A.C., et al.

Differential effects of paraquat on oxidative stress parameters and polyamine levels in two freshwater invertebrates
por: Cochón, Adriana Cristina, et al.
Publicado: (2007)

Superoxide scavenging and antimicrobial activities of novel transition metal complexes of oxydiacetate dianion as primary ligand: Spectral characterization, cyclic voltammetric investigations and crystal structure
por: Siddiqi, Z.A., et al.

Differential efficiency of two strains of the arbuscular mycorrhizal fungus Rhizophagus irregularis on olive (Olea europaea) plants under two water regimes
por: Bompadre, M.J., et al.

N-acetylcysteine reduces markers of differentiation in 3T3-L1 adipocytes
por: Calzadilla, Pablo Ignacio, et al.
Publicado: (2011)

N-acetylcysteine reduces markers of differentiation in 3T3-L1 adipocytes
por: Calzadilla, P., et al.
Publicado: (2011)

N-acetylcysteine reduces markers of differentiation in 3T3-L1 adipocytes
por: Calzadilla, P., et al.

N-acetylcysteine reduces markers of differentiation in 3T3-L1 adipocytes
por: Calzadilla, P., et al.
Publicado: (2011)

Protective action of antioxidants on hepatic damage induced by griseofulvin
por: Martinez, M.D.C., et al.