Repression of 5-aminolevulinate synthase gene by the potent tumor promoter, TPA, involves multiple signal transduction pathways

The potent tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) induces activator protein-1 (AP-1) transcription factors, early response genes involved in a diverse set of transcriptional regulatory processes, and protein kinase C (PKC) activity. This work was designed to explore the signal tr...

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Detalles Bibliográficos
Autores principales: Guberman, A.S., Scassa, M.E., Cánepa, E.T.
Formato: JOUR
Materias:
12-O-Tetradecanoylphorbol-13-acetate
5-Aminolevulinate synthase
c-Jun N-terminal kinase
Extracellular-signal regulated kinase
Phosphatidyl inositol 3-kinase
Protein phosphorylation
Regulation of gene expression
Signal transduction
Tumor promoter
2 (2 amino 3 methoxyphenyl)chromone
5 aminolevulinate synthase
anthra[1,9 cd]pyrazol 6(2h) one
chloramphenicol acetyltransferase
cyclic AMP responsive element binding protein binding protein
heme
mevinolin
mitochondrial enzyme
mitogen activated protein kinase 1
pd 152440
phorbol 13 acetate 12 myristate
phorbol ester
phosphatidylinositol 3 kinase
protein farnesyltransferase inhibitor
protein kinase C alpha
Raf protein
Ras protein
regulator protein
stress activated protein kinase
tumor promoter
wortmannin
article
catalysis
cell membrane permeability
controlled study
enzyme activation
enzyme regulation
gene activity
gene expression
gene repression
hepatoma cell
human
human cell
priority journal
reporter gene
signal transduction
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00039861_v436_n2_p285_Guberman
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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