How mitogen-activated protein kinases recognize and phosphorylate their targets: A QM/MM study

Mitogen-activated protein kinase (MAPK) signaling pathways play an essential role in the transduction of environmental stimuli to the nucleus, thereby regulating a variety of cellular processes, including cell proliferation, differentiation, and programmed cell death. The components of the MAPK extr...

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Detalles Bibliográficos
Autores principales: Turjanski, A.G., Hummer, G., Gutkind, J.S.
Formato: JOUR
Materias:
Activated proteins
Active site
Cancer therapy
Catalytic base
Cellular process
Complex structure
Environmental stimuli
Extracellular
Human cancer
Kinase activity
Mitogen activated protein kinase
Molecular events
One step
Phospho-transfer
Phosphoryl transfer
Phosphorylation reactions
Programmed cell deaths
Proline residues
Reaction mechanism
Signaling pathways
Transition state
Amines
Cell death
Cell membranes
Cell proliferation
Enzyme activity
Molecular mechanics
Targets
magnesium
mitogen activated protein kinase
mitogen activated protein kinase 1
proline
serine
threonine
peptide
article
catalysis
enzyme phosphorylation
molecular mechanics
molecular recognition
protein analysis
protein function
protein interaction
quantum mechanics
chemical model
chemical structure
chemistry
computer simulation
conformation
enzyme active site
metabolism
phosphorylation
quantum theory
synthesis
Catalysis
Catalytic Domain
Computer Simulation
Mitogen-Activated Protein Kinases
Models, Chemical
Models, Molecular
Molecular Conformation
Peptides
Phosphorylation
Quantum Theory
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00027863_v131_n17_p6141_Turjanski
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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