Host Cell Poly(ADP-Ribose) Glycohydrolase Is Crucial for Trypanosoma cruzi Infection Cycle

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Trypanosoma cruzi, etiological agent of Chagas' disease, has a complex life cycle which involves the invasion of mammalian host cells, differentiation and intracellular replication. Here we report the first insights into the biological role of a poly(ADP-ribose) glycohydrolase in a trypanosomat...

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Detalles Bibliográficos
Autores principales: Vilchez Larrea, S.C., Schlesinger, M., Kevorkian, M.L., Flawiá, M.M., Alonso, G.D., Fernández Villamil, S.H.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2013
Materias:
antibody
cell enzyme
DNA
glycosidase inhibitor
hydroxyurea
poly(adenosine diphosphate ribose)
poly(adenosine diphosphate ribose) glycohydrolase
RNA
unclassified drug
article
catalysis
cell cycle progression
cell nucleus
Chagas disease
concentration (parameters)
DNA damage
electron microscopy
enzyme localization
epimastigote
gene
gene expression
genetic analysis
genetic conservation
growth rate
host cell
human
human cell
immunofluorescence test
in vitro study
kinetoplastid life cycle stage
Kinetoplastida
nonhuman
nucleotide sequence
RNA interference
TcPARG gene
Trypanosoma cruzi
trypomastigote
Vero cell
Western blotting
Adenosine Diphosphate
Animals
Blotting, Northern
Blotting, Southern
Blotting, Western
Catalysis
Cell Cycle
Cell Line, Tumor
Cercopithecus aethiops
Chagas Disease
Fluorescent Antibody Technique, Indirect
Glycoside Hydrolases
Humans
Hydroxyurea
Life Cycle Stages
Microscopy, Electron
Pyrrolidines
Vero Cells
Mammalia
Trypanosomatidae
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19326203_v8_n6_p_VilchezLarrea
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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