Oxygen sensing in Drosophila: Multiple isoforms of the prolyl hydroxylase fatiga have different capacity to regulate HIFαSima

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Background: The Hypoxia Inducible Factor (HIF) mediates cellular adaptations to low oxygen. Prolyl-4-hydroxylases are oxygen sensors that hydroxylate the HIF alpha-subunit, promoting its proteasomal degradation in normoxia. Three HIFprolyl hydroxylases, encoded by independent genes, PHD1, PHD2, and...

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Detalles Bibliográficos
Autores principales: Acevedo, J.M., Centanin, L., Dekanty, A., Wappner, P.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2010
Materias:
hypoxia inducible factor
oxygenase
polyhistidine tag
procollagen proline 2 oxoglutarate 4 dioxygenase
prolyl 4 hydroxylase 1
prolyl 4 hydroxylase 2
prolyl 4 hydroxylase 3
unclassified drug
DNA binding protein
Drosophila protein
isoenzyme
messenger RNA
oxygen
Sima protein, Drosophila
alternative RNA splicing
animal cell
article
cell hypoxia
controlled study
Drosophila
embryo
gene expression regulation
gene locus
gene overexpression
imago
in vivo study
insect cell culture
intron
loss of function mutation
molecular dynamics
nonhuman
oxygen sensing
phenotypic variation
protein domain
protein localization
transcription initiation site
transgenics
animal
anoxia
chemistry
DNA responsive element
Drosophila melanogaster
enzymology
genetics
growth, development and aging
human
life cycle
metabolism
protein tertiary structure
upregulation
Mammalia
Alternative Splicing
Animals
Anoxia
DNA-Binding Proteins
Drosophila Proteins
Gene Expression Regulation, Enzymologic
Genetic Loci
Humans
Isoenzymes
Life Cycle Stages
Oxygen
Procollagen-Proline Dioxygenase
Protein Structure, Tertiary
Response Elements
RNA, Messenger
Up-Regulation
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19326203_v5_n8_p_Acevedo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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