Cell Autonomy of HIF Effects in Drosophila: Tracheal Cells Sense Hypoxia and Induce Terminal Branch Sprouting

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Drosophila tracheal terminal branches are plastic and have the capacity to sprout out projections toward oxygen-starved areas, in a process analogous to mammalian angiogenesis. This response involves the upregulation of FGF/Branchless in hypoxic tissues, which binds its receptor Breathless on trache...

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Detalles Bibliográficos
Autores principales: Centanin, L., Dekanty, A., Romero, N., Irisarri, M., Gorr, T.A., Wappner, P.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2008
Materias:
DEVBIO
cell protein
fibroblast growth factor receptor
hypoxia inducible factor alpha
ligand
procollagen proline 2 oxoglutarate 4 dioxygenase
protein Fatiga
transcription factor
transcription factor Branchless
transcription factor Breathless
transcription factor Sima
unclassified drug
angiogenesis
animal cell
article
cell hypoxia
controlled study
Drosophila
embryo
gene overexpression
nonhuman
organogenesis
oxygen sensing
phenotype
priority journal
protein expression
protein localization
tissue oxygenation
trachea
wild type
Animals
Anoxia
Body Patterning
DNA-Binding Proteins
Drosophila melanogaster
Drosophila Proteins
Fibroblast Growth Factors
Gene Expression Regulation, Developmental
Hypoxia-Inducible Factor 1, alpha Subunit
Larva
Oxygen
Phenotype
Procollagen-Proline Dioxygenase
Protein-Tyrosine Kinases
Receptors, Fibroblast Growth Factor
Mammalia
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_15345807_v14_n4_p547_Centanin
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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