MageA2 restrains cellular senescence by targeting the function of PMLIV/p53 axis at the PML-NBs

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MAGE-A genes are a subfamily of the melanoma antigen genes (MAGEs), whose expression is restricted to tumor cells of different origin and normal tissues of the human germline. Although the specific function of individual MAGE-A proteins is being currently explored, compelling evidence suggest their...

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Detalles Bibliográficos
Autores principales: Peche, L.Y., Scolz, M., Ladelfa, M.F., Monte, M., Schneider, C.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2012
Materias:
Acetylation
MAGE
P53
PML
Senescence
Sumoylation
melanoma antigen 2
PMLIV protein
promyelocytic leukemia protein
protein p53
Ras protein
tumor suppressor protein
unclassified drug
apoptosis
article
cell aging
cell count
cell nucleus inclusion body
cell proliferation
controlled study
fibroblast
gene expression
gene targeting
histone acetylation
human
human cell
leukemia cell
oncogene
priority journal
promyelocytic leukemia
promyelocytic leukemia nuclear bodies
protein analysis
protein function
protein induction
protein localization
protein processing
protein protein interaction
senescence
sumoylation
transcription initiation
tumor suppressor gene
Apoptosis
Cell Aging
Cell Line, Tumor
Fibroblasts
HEK293 Cells
Histone Deacetylases
Humans
Intranuclear Inclusion Bodies
Melanoma-Specific Antigens
Neoplasm Proteins
Nuclear Proteins
Protein Interaction Mapping
ras Proteins
RNA Interference
RNA, Small Interfering
Transcription Factors
Tumor Suppressor Protein p53
Tumor Suppressor Proteins
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_13509047_v19_n6_p926_Peche
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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