Sulfates are main targets of immune responses to cruzipain and are involved in heart damage in BALB/c immunized mice

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Trypanosoma cruzi, the agent of Chagas disease contains a major cysteine proteinase, cruzipain (Cz), with an unusual carboxyl-terminal extension (C-T). We have previously reported the presence of sulfate groups in the N-linked oligosaccharide chains of this domain. In order to evaluate the immune re...

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Detalles Bibliográficos
Autores principales: Acosta, D.M., Arnaiz, M.R., Esteva, M.I., Barboza, M., Stivale, D., Orlando, U.D., Torres, S., Laucella, S.A., Couto, A.S., Duschak, V.G.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2008
Materias:
C-T domain
Cruzipain
Glycoprotein
Sulfated epitopes
Trypanosoma cruzi
antigen
cruzipain
epitope
immunoglobulin G antibody
immunoglobulin G2b
sulfate
animal experiment
animal model
animal tissue
article
Bagg albino mouse
carboxy terminal sequence
cellular immunity
controlled study
delayed hypersensitivity
disease course
disease severity
enzyme activity
female
heart injury
humoral immunity
immunization
immunopathogenesis
immunoreactivity
memory T lymphocyte
mouse
nonhuman
parasitosis
priority journal
protein domain
protein targeting
serology
Animals
Chagas Disease
Chronic Disease
Cysteine Endopeptidases
Disease Models, Animal
Female
Heart Diseases
Humans
Hypersensitivity, Delayed
Immunoglobulin G
Injections, Subcutaneous
Mice
Mice, Inbred BALB C
Myocardium
Peptide Fragments
Protein Structure, Tertiary
Reproducibility of Results
Serologic Tests
Sulfates
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09538178_v20_n4_p461_Acosta
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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