Porphyrin synthesis from ALA derivatives for photodynamic therapy. In vitro and in vivo studies

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The aim of this work was to test in vitro and in vivo the efficacy of the derivatives of 5-aminolevulinic acid (ALA): hexyl-ALA (He-ALA), undecanoyl-ALA and R,S-2-(hydroximethyl)tetrahydropyranyl-ALA (THP-ALA) as pro-photosensitising agents. The compounds were assayed in a cell line derived from a m...

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Detalles Bibliográficos
Autores principales:	Perotti, C., Fukuda, H., DiVenosa, G., MacRobert, A.J., Batlle, A., Casas, A.
Formato:	Artículo publishedVersion
Lenguaje:	Inglés
Publicado:	2004
Materias:	ALA ALA derivatives Aminolevulinic acid PDT Photodynamic therapy 2 (hydroxymethyl)tetrahydropyranyl 5 aminolevulinic acid aminolevulinic acid hexyl 5 aminolevulinic acid photosensitizing agent porphyrin unclassified drug undecanoyl 5 aminolevulinic acid drug derivative animal cell animal experiment animal model animal tissue article bioaccumulation breast tumor cell line controlled study correlation analysis drug determination drug efficacy drug uptake explant ion exchange chromatography male mouse nonhuman photodynamic therapy phototoxicity porphyrin metabolism priority journal animal Bagg albino mouse biosynthesis chemistry experimental neoplasm methodology photochemotherapy Aminolevulinic Acid Animals Male Mammary Neoplasms, Animal Mice Mice, Inbred BALB C Photochemotherapy Photosensitizing Agents Porphyrins
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00070920_v90_n8_p1660_Perotti
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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