Polymeric Prosthetic Systems for Site-Specific Drug Administration: Physical and Chemical Properties
Polymeric materials having biomedical applications can be classified into two major groups according to their use: those employed in prosthetic devices, such as cardiovascular and orthopedic prostheses; and those employed as therapeutic systems, such as drug carriers. Among prosthetic systems, polym...
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2015
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97811190_v1_n_p369_Parisi http://hdl.handle.net/20.500.12110/paper_97811190_v1_n_p369_Parisi |
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| Sumario: | Polymeric materials having biomedical applications can be classified into two major groups according to their use: those employed in prosthetic devices, such as cardiovascular and orthopedic prostheses; and those employed as therapeutic systems, such as drug carriers. Among prosthetic systems, polymeric materials can be used as coatings or as cemented prostheses. Some of the major advantages in using polymeric materials for biomedical applications are their flexibility, biocompatibility, the possibility of tailoring their mechanical properties and their ability to incorporate therapeutic agents into their matrix in order to allow drug administration at a specific site. The aim of this chapter is to summarize the uses and applications in the field of medical devices, as well as to discuss the pharmaceutical, physical and chemical properties of two of the most popular biomedical polymers: poly(methyl methacrylate) and polyurethanes (PU). In particular, we will center our attention on their use as site-specific drug administration and their application in two great areas of prosthetic devices, bone tissue and cardiovascular engineering. We will also cover their use in diagnosis and in therapeutic treatments along with advances and future perspectives in both areas. © 2015 Scrivener Publishing LLC. All rights reserved. |
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