The IFNG rs1861494 single nucleotide polymorphism is associated with protection against tuberculosis disease in Argentina

Interferon gamma (IFNG) plays a key role during Mycobacterium tuberculosis (Mtb) infection, and several polymorphisms located in its gene are associated with risk of tuberculosis in diverse populations. Nevertheless, the genetic resistance/susceptibility to tuberculosis in Argentina is unknown. The...

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Detalles Bibliográficos
Publicado: 2018
Materias:
Interferon gamma
Mycobacterium tuberculosis
Rs1861494
Single nucleotide polymorphism
Tuberculosis
biological marker
CD4 antigen
gamma interferon
Mycobacterium antigen
adult
allele
Argentina
Article
bacterial strain
case control study
CD4+ T lymphocyte
controlled study
disease resistance
disease severity
female
gene frequency
gene function
gene location
genetic association
genetic variation
genotype
human
human cell
IFNG gene
immune response
major clinical study
male
nonhuman
peripheral blood mononuclear cell
single nucleotide polymorphism
tuberculosis
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_20734425_v9_n1_p_Rolandelli
http://hdl.handle.net/20.500.12110/paper_20734425_v9_n1_p_Rolandelli
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Interferon gamma (IFNG) plays a key role during Mycobacterium tuberculosis (Mtb) infection, and several polymorphisms located in its gene are associated with risk of tuberculosis in diverse populations. Nevertheless, the genetic resistance/susceptibility to tuberculosis in Argentina is unknown. The IFNG rs1861494 polymorphism (G→A) was reported to alter the binding of transcription factors to this region, influencing IFNG production. Using a case-control study, we found an association between the AA and AG genotypes and tuberculosis resistance (AA vs. GG: odds ratio (OR) = 0.235, p-value = 0.012; AG vs. GG: OR = 0.303, p-value = 0.044; AA vs. AG: OR = 0.776, p-value = 0.427; AA + AG vs. GG: OR = 0.270, p-value = 0.022). Moreover, Mtb-antigen stimulated peripheral blood mononuclear cells (PBMCs) from healthy donors and AA carriers secreted the highest amounts of IFNG in culture supernatants (p-value = 0.034) and presented the greatest percentage of CD4+IFNG+ lymphocytes (p-value = 0.035), in comparison with GG carriers. No association between the polymorphism and clinical parameters of tuberculosis severity was detected. However, our findings indicate that the rs1861494 single nucleotide polymorphism (SNP) could be considered as a biomarker of tuberculosis resistance in the Argentinean population. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.

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