Ligand uptake in Mycobacterium tuberculosis truncated hemoglobins is controlled by both internal tunnels and active site water molecules

Mycobacterium tuberculosis, the causative agent of human tuberculosis, has two proteins belonging to the truncated hemoglobin (trHb) family. Mt-trHbN presents well-defined internal hydrophobic tunnels that allow O 2 and •NO to migrate easily from the solvent to the active site, whereas Mt-trHbO poss...

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Detalles Bibliográficos
Autores principales:	Boechi, Leonardo, Bustamante, Juan Pablo, Estrin, Dario Ariel, Martí, Marcelo Adrián
Publicado:	2015
Materias:	carbon monoxide nitric oxide truncated hemoglobin active site water molecule Article bacterial kinetics computer model controlled study decomposition internal tunnel molecular dynamics molecule mutant mutation Mycobacterium tuberculosis protein structure wild type
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_20461402_v4_n_p_Boechi http://hdl.handle.net/20.500.12110/paper_20461402_v4_n_p_Boechi
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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