Deletion of A44L, A46R and C12L vaccinia virus genes from the MVA genome improved the vector immunogenicity by modifying the innate immune response generating enhanced and optimized specific T-cell responses

MVA is an attenuated vector that still retains immunomodulatory genes. We have previously reported its optimization after deleting the C12L gene, coding for the IL-18 binding-protein. Here, we analyzed the immunogenicity of MVA vectors harboring the simultaneous deletion of A44L, related to steroid...

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Detalles Bibliográficos
Autores principales: Holgado, María Pía, Falivene, Juliana, Maeto, Cynthia A., Bruttomesso, Andrea Claudia, Calamante, Gabriela, Del Médico Zajac, María Paula, Gherardi, María Magdalena
Publicado: 2016
Materias:
MVA
T-cell response
Vaccine
beta interferon
gamma interferon
interleukin 12
interleukin 18 binding protein
interleukin 1beta
virus vaccine
A46R protein, vaccinia virus
C12L protein, vaccinia virus
cytokine
epitope
viral protein
virus antigen
A44L gene
A46R gene
animal cell
Article
C12L gene
cell proliferation
controlled study
cytokine production
cytotoxicity
enzyme linked immunospot assay
female
gene deletion
gene expression
gene sequence
immune response
immunofluorescence
immunogenicity
mouse
nonhuman
reverse transcription polymerase chain reaction
RNA extraction
spleen cell
T lymphocyte
Vaccinia virus
virus gene
animal
C57BL mouse
genetics
immunology
innate immunity
lymph node
secretion (process)
spleen
Animals
Antigens, Viral
Cytokines
Epitopes
Immunity, Innate
Lymph Nodes
Mice, Inbred C57BL
Sequence Deletion
Spleen
T-Lymphocytes
Viral Proteins
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19994915_v8_n5_p_Holgado
http://hdl.handle.net/20.500.12110/paper_19994915_v8_n5_p_Holgado
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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