Targeting of arenavirus RNA synthesis by a carboxamide-derivatized aromatic disulfide with virucidal activity

Several arenaviruses can cause severe hemorrhagic fever (HF) in humans, representing a public health threat in endemic areas of Africa and South America. The present study characterizes the potent virucidal activity of the carboxamide-derivatized aromatic disulfide NSC4492, an antiretroviral zinc fi...

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Detalles Bibliográficos
Autores principales: Sepúlveda, Claudia Soledad, García, Cybele Carina, López, Nora Mabel, Damonte, Elsa Beatriz
Publicado: 2013
Materias:
antivirus agent
disulfide
hydrazine derivative
NSC4492
virus RNA
animal
Arenavirus
cell line
Chlorocebus aethiops
dose response
drug effects
genetic transcription
genetics
human
physiology
temperature
Vero cell line
virus release
virus replication
Animals
Antiviral Agents
Cell Line
Cercopithecus aethiops
Disulfides
Dose-Response Relationship, Drug
Humans
Hydrazines
RNA, Viral
Temperature
Transcription, Genetic
Vero Cells
Virus Release
Virus Replication
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19326203_v8_n11_p_Sepulveda
http://hdl.handle.net/20.500.12110/paper_19326203_v8_n11_p_Sepulveda
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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