The Alternative Epac/cAMP Pathway and the MAPK Pathway Mediate hCG Induction of Leptin in Placental Cells

Pleiotropic effects of leptin have been identified in reproduction and pregnancy, particularly in the placenta, where it works as an autocrine hormone. In this work, we demonstrated that human chorionic gonadotropin (hCG) added to JEG-3 cell line or to placental explants induces endogenous leptin ex...

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Detalles Bibliográficos
Autores principales:	Maymó, Julieta L., Calvo, Juan Carlos, Varone, Cecilia Laura
Publicado:	2012
Materias:	chorionic gonadotropin cyclic AMP cyclic AMP dependent protein kinase cyclic AMP dependent protein kinase inhibitor cyclic AMP derivative cyclic AMP responsive element binding protein EPAC protein exchange protein directly activated by cyclic AMP leptin messenger RNA mitogen activated protein kinase mitogen activated protein kinase 1 n [2 (4 bromocinnamylamino)ethyl] 5 isoquinolinesulfonamide protein Rap1 protein unclassified drug article Bewo cell cell line cell strain JEG 3 controlled study cyclic AMP responsive element enzyme activation enzyme inhibition enzyme phosphorylation explant gene activity genetic transfection human human cell human tissue placenta plasmid promoter region protein expression protein induction signal transduction Base Sequence Blotting, Western Cell Line, Tumor Chorionic Gonadotropin Cyclic AMP Cyclic AMP-Dependent Protein Kinases DNA Primers Enzyme Activation Female Guanine Nucleotide Exchange Factors Humans Leptin MAP Kinase Signaling System Placenta Pregnancy Real-Time Polymerase Chain Reaction
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19326203_v7_n10_p_Maymo http://hdl.handle.net/20.500.12110/paper_19326203_v7_n10_p_Maymo
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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