Oxygen sensing in Drosophila: Multiple isoforms of the prolyl hydroxylase fatiga have different capacity to regulate HIFαSima

Background: The Hypoxia Inducible Factor (HIF) mediates cellular adaptations to low oxygen. Prolyl-4-hydroxylases are oxygen sensors that hydroxylate the HIF alpha-subunit, promoting its proteasomal degradation in normoxia. Three HIFprolyl hydroxylases, encoded by independent genes, PHD1, PHD2, and...

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Detalles Bibliográficos
Autores principales:	Acevedo, Julieta María, Centanin, Lázaro, Dekanty, Andrés, Wappner, Pablo
Publicado:	2010
Materias:	hypoxia inducible factor oxygenase polyhistidine tag procollagen proline 2 oxoglutarate 4 dioxygenase prolyl 4 hydroxylase 1 prolyl 4 hydroxylase 2 prolyl 4 hydroxylase 3 unclassified drug DNA binding protein Drosophila protein isoenzyme messenger RNA oxygen Sima protein, Drosophila alternative RNA splicing animal cell article cell hypoxia controlled study Drosophila embryo gene expression regulation gene locus gene overexpression imago in vivo study insect cell culture intron loss of function mutation molecular dynamics nonhuman oxygen sensing phenotypic variation protein domain protein localization transcription initiation site transgenics animal anoxia chemistry DNA responsive element Drosophila melanogaster enzymology genetics growth, development and aging human life cycle metabolism protein tertiary structure upregulation Mammalia Alternative Splicing Animals Anoxia DNA-Binding Proteins Drosophila Proteins Gene Expression Regulation, Enzymologic Genetic Loci Humans Isoenzymes Life Cycle Stages Oxygen Procollagen-Proline Dioxygenase Protein Structure, Tertiary Response Elements RNA, Messenger Up-Regulation
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19326203_v5_n8_p_Acevedo http://hdl.handle.net/20.500.12110/paper_19326203_v5_n8_p_Acevedo
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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