TuberQ: A Mycobacterium tuberculosis protein druggability database

In 2012 an estimated 8.6 million people developed tuberculosis (TB) and 1.3 million died from the disease [including 320 000 deaths among human immunodeficiency virus (HIV)-positive people]. There is an urgent need for new anti-TB drugs owing to the following: the fact that current treatments have s...

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Autores principales:	Defelipe, Lucas Alfredo, Martí, Marcelo Adrián, Turjanski, Adrián Gustavo
Publicado:	2014
Materias:	bacterial protein tuberculostatic agent article chemistry data base Internet metabolism Mycobacterium tuberculosis protein database protein tertiary structure Antitubercular Agents Bacterial Proteins Database Management Systems Databases, Protein Protein Structure, Tertiary
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_17580463_v2014_n_p_Radusky http://hdl.handle.net/20.500.12110/paper_17580463_v2014_n_p_Radusky
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_17580463_v2014_n_p_Radusky
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spelling	paper:paper_17580463_v2014_n_p_Radusky2023-06-08T16:28:58Z TuberQ: A Mycobacterium tuberculosis protein druggability database Defelipe, Lucas Alfredo Martí, Marcelo Adrián Turjanski, Adrián Gustavo bacterial protein tuberculostatic agent article chemistry data base Internet metabolism Mycobacterium tuberculosis protein database protein tertiary structure Antitubercular Agents Bacterial Proteins Database Management Systems Databases, Protein Internet Mycobacterium tuberculosis Protein Structure, Tertiary In 2012 an estimated 8.6 million people developed tuberculosis (TB) and 1.3 million died from the disease [including 320 000 deaths among human immunodeficiency virus (HIV)-positive people]. There is an urgent need for new anti-TB drugs owing to the following: the fact that current treatments have severe side effects, the increasing emergence of multi-drug-resistant strains of Mycobacterium tuberculosis (Mtb), the negative drug-drug interactions with certain HIV (or other disease) treatments and the ineffectiveness against dormant Mtb. In this context we present here the TuberQ database, a novel resource for all researchers working in the field of drug development in TB. The main feature of TuberQ is to provide a druggability analysis of Mtb proteins in a consistent and effective manner, contributing to a better selection of potential drug targets for screening campaigns and the analysis of targets for structure-based drug design projects. The structural druggability analysis is combined with features related to the characteristics of putative inhibitor binding pockets and with functional and biological data of proteins. The structural analysis is performed on all available unique Mtb structures and high-quality structural homology-based models. This information is shown in an interactive manner, depicting the protein structure, the pockets and the associated characteristics for each protein. TuberQ also provides information about gene essentiality information, as determined from whole cell-based knockout experiments, and expression information obtained from microarray experiments done in different stress-related conditions. We hope that TuberQ will be a powerful tool for researchers working in TB and eventually will lead to the identification of novel putative targets and progresses in therapeutic activities. © The Author(s) 2014. Fil:Defelipe, L.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Marti, M.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Turjanski, A.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_17580463_v2014_n_p_Radusky http://hdl.handle.net/20.500.12110/paper_17580463_v2014_n_p_Radusky
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	bacterial protein tuberculostatic agent article chemistry data base Internet metabolism Mycobacterium tuberculosis protein database protein tertiary structure Antitubercular Agents Bacterial Proteins Database Management Systems Databases, Protein Internet Mycobacterium tuberculosis Protein Structure, Tertiary
spellingShingle	bacterial protein tuberculostatic agent article chemistry data base Internet metabolism Mycobacterium tuberculosis protein database protein tertiary structure Antitubercular Agents Bacterial Proteins Database Management Systems Databases, Protein Internet Mycobacterium tuberculosis Protein Structure, Tertiary Defelipe, Lucas Alfredo Martí, Marcelo Adrián Turjanski, Adrián Gustavo TuberQ: A Mycobacterium tuberculosis protein druggability database
topic_facet	bacterial protein tuberculostatic agent article chemistry data base Internet metabolism Mycobacterium tuberculosis protein database protein tertiary structure Antitubercular Agents Bacterial Proteins Database Management Systems Databases, Protein Internet Mycobacterium tuberculosis Protein Structure, Tertiary
description	In 2012 an estimated 8.6 million people developed tuberculosis (TB) and 1.3 million died from the disease [including 320 000 deaths among human immunodeficiency virus (HIV)-positive people]. There is an urgent need for new anti-TB drugs owing to the following: the fact that current treatments have severe side effects, the increasing emergence of multi-drug-resistant strains of Mycobacterium tuberculosis (Mtb), the negative drug-drug interactions with certain HIV (or other disease) treatments and the ineffectiveness against dormant Mtb. In this context we present here the TuberQ database, a novel resource for all researchers working in the field of drug development in TB. The main feature of TuberQ is to provide a druggability analysis of Mtb proteins in a consistent and effective manner, contributing to a better selection of potential drug targets for screening campaigns and the analysis of targets for structure-based drug design projects. The structural druggability analysis is combined with features related to the characteristics of putative inhibitor binding pockets and with functional and biological data of proteins. The structural analysis is performed on all available unique Mtb structures and high-quality structural homology-based models. This information is shown in an interactive manner, depicting the protein structure, the pockets and the associated characteristics for each protein. TuberQ also provides information about gene essentiality information, as determined from whole cell-based knockout experiments, and expression information obtained from microarray experiments done in different stress-related conditions. We hope that TuberQ will be a powerful tool for researchers working in TB and eventually will lead to the identification of novel putative targets and progresses in therapeutic activities. © The Author(s) 2014.
author	Defelipe, Lucas Alfredo Martí, Marcelo Adrián Turjanski, Adrián Gustavo
author_facet	Defelipe, Lucas Alfredo Martí, Marcelo Adrián Turjanski, Adrián Gustavo
author_sort	Defelipe, Lucas Alfredo
title	TuberQ: A Mycobacterium tuberculosis protein druggability database
title_short	TuberQ: A Mycobacterium tuberculosis protein druggability database
title_full	TuberQ: A Mycobacterium tuberculosis protein druggability database
title_fullStr	TuberQ: A Mycobacterium tuberculosis protein druggability database
title_full_unstemmed	TuberQ: A Mycobacterium tuberculosis protein druggability database
title_sort	tuberq: a mycobacterium tuberculosis protein druggability database
publishDate	2014
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_17580463_v2014_n_p_Radusky http://hdl.handle.net/20.500.12110/paper_17580463_v2014_n_p_Radusky
work_keys_str_mv	AT defelipelucasalfredo tuberqamycobacteriumtuberculosisproteindruggabilitydatabase AT martimarceloadrian tuberqamycobacteriumtuberculosisproteindruggabilitydatabase AT turjanskiadriangustavo tuberqamycobacteriumtuberculosisproteindruggabilitydatabase
_version_	1768543580009267200

TuberQ: A Mycobacterium tuberculosis protein druggability database

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