The druggable pocketome of Corynebacterium diphtheriae: A new approach for in silico putative druggable targets

Diphtheria is an acute and highly infectious disease, previously regarded as endemic in nature but vaccine-preventable, is caused by Corynebacterium diphtheriae (Cd). In this work, we used an in silico approach along the 13 complete genome sequences of C. diphtheriae followed by a computational asse...

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Detalles Bibliográficos
Publicado: 2018
Materias:
Corynebacterium diphtheria
Druggable genome
Global druggable (GD)
Highly druggable (HD)
Pocketome
Putative therapeutic targets
Structural proteomics
adenosine triphosphate phosphoribosyltransferase
apyrase
fructose 1,6 bisphosphate
fructose bisphosphatase
new drug
proteome
ribosome protein
amino acid sequence
Article
binding site
cellular distribution
computer model
conserved sequence
Corynebacterium diphtheriae
drug database
drug targeting
druggable pocketome
enzyme active site
gene fusion
gene sequence
infectious agent
nonhuman
open reading frame
Protein Data Bank
protein protein interaction
sequence homology
structural model
structural proteomics
structure analysis
three dimensional imaging
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16648021_v9_nFEB_p_Hassan
http://hdl.handle.net/20.500.12110/paper_16648021_v9_nFEB_p_Hassan
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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