Primary immunodeficiencies unravel the role of IL-2/CD25/STAT5b in human natural killer cell maturation

Natural killer (NK) cells play a pivotal role during immunity against viruses and circumstantial evidence also indicates that they can protect the host against developing tumors. Peripheral blood NK cells comprise CD56brightCD16lo/- cells that constitutively express CD25 (IL-2Ra) and CD56dimCD16hi c...

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Detalles Bibliográficos
Publicado:	2018
Materias:	CD25 IL-2 Natural killer cells Primary immunodeficiencies STAT5b CD16 antigen CD3 antigen CD56 antigen chemokine receptor CCR7 gamma interferon granzyme B interleukin 15 interleukin 2 interleukin 2 receptor alpha L selectin monoclonal antibody nerve cell adhesion molecule perforin STAT5b protein Article atopic dermatitis autoimmune thyroiditis case report cell count cell maturation cell proliferation assay chronic diarrhea clinical article controlled study cytokine production degranulation assay down regulation eczema female flow cytometry growth disorder human human cell immune deficiency immunohistochemistry lower respiratory tract infection natural killer cell peripheral blood mononuclear cell phenotype pneumonia protein expression signal transduction upregulation
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16643224_v9_nJUN_p_Caldirola http://hdl.handle.net/20.500.12110/paper_16643224_v9_nJUN_p_Caldirola
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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