Induction of ATP release, PPIX transport, and cholesterol uptake by human red blood cells using a new family of TSPO ligands

Two main isoforms of the Translocator Protein (TSPO) have been identified. TSPO1 is ubiquitous and is mainly present at the outer mitochondrial membrane of most eukaryotic cells, whereas, TSPO2 is specific to the erythroid lineage, located at the plasma membrane, the nucleus, and the endoplasmic ret...

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Detalles Bibliográficos
Publicado:	2018
Materias:	ATP Erythrocyte Malaria Plasmodium Red blood cell TSPO TSPO2 VDAC ZnPPIX adenine nucleotide translocase adenosine triphosphate antiparasitic agent carrier protein ligand n sec butyl 1 (2 chlorophenyl) n methyl 3 isoquinolinecarboxamide n,n diethyl 2 (2 (furan 2 yl) 5 oxoimidazo[1 c]quinazolin 6(5h) yl)acetamide n,n diethyl 2 (2 (furan 2 yl) 5 oxomidazo[1 c]quinazolin 6(5h) yl)acetamide n,n dipropyl 2 (5 oxo 2 phenylimidazo[1 c]quinazolin 6(5h) yl)acetamide protoporphyrin zinc radioligand reactive oxygen metabolite Ro5 4864 sorbitol SSR 180 575 ubiquitin unclassified drug voltage dependent anion channel 4 aminobutyric acid receptor cholesterol protein binding protoporphyrin TSPO protein, human antimalarial activity Article binding affinity blood flow cholesterol transport comparative study controlled study erythrocyte erythrocyte function and characteristics erythrocyte lifespan erythrocyte membrane flow cytometry fluorescence growth inhibition hematocrit hemolysis assay human human cell IC50 malaria falciparum normal human parasitemia plasmodium (life cycle stage) protein analysis protein transport supramolecular chemistry tissue oxygenation drug effect hemolysis metabolism Plasmodium falciparum transport at the cellular level Adenosine Triphosphate Biological Transport Cholesterol Erythrocytes Hemolysis Humans Ligands Protein Binding Protoporphyrins Reactive Oxygen Species Receptors, GABA Sorbitol
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16616596_v19_n10_p_MarginedasFreixa http://hdl.handle.net/20.500.12110/paper_16616596_v19_n10_p_MarginedasFreixa
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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