Stochastic fire-diffuse-fire model with realistic cluster dynamics
Living organisms use waves that propagate through excitable media to transport information. Ca2 + waves are a paradigmatic example of this type of processes. A large hierarchy of Ca2 + signals that range from localized release events to global waves has been observed in Xenopus laevis oocytes. In th...
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| Autores principales: | , |
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2010
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15393755_v82_n3_p_Calabrese http://hdl.handle.net/20.500.12110/paper_15393755_v82_n3_p_Calabrese |
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| Sumario: | Living organisms use waves that propagate through excitable media to transport information. Ca2 + waves are a paradigmatic example of this type of processes. A large hierarchy of Ca2 + signals that range from localized release events to global waves has been observed in Xenopus laevis oocytes. In these cells, Ca2 + release occurs trough inositol 1,4,5-trisphosphate receptors (IP 3 Rs) which are organized in clusters of channels located on the membrane of the endoplasmic reticulum. In this article we construct a stochastic model for a cluster of IP 3 R 's that replicates the experimental observations reported in. We then couple this phenomenological cluster model with a reaction-diffusion equation, so as to have a discrete stochastic model for calcium dynamics. The model we propose describes the transition regimes between isolated release and steadily propagating waves as the IP 3 concentration is increased. © 2010 The American Physical Society. |
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