Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/ KDR

The G protein-coupled receptor oncogene (vGPCR) of the Kaposi's sarcoma (KS) associated herpesvirus (KSHV), an oncovirus implicated in angioproliferative neoplasms, induces angiogenesis by VEGF secretion. Accordingly, we found that expression of vGPCR in human umbilical vein endothelial cells (...

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Detalles Bibliográficos
Autores principales:	Bais, Carlos E., Mesri, Enrique Alfredo
Publicado:	2003
Materias:	G protein coupled receptor vasculotropin receptor 2 virus protein AKT1 protein, human chemokine receptor endothelial cell growth factor G protein coupled receptor, Human herpesvirus 8 G protein-coupled receptor, Human herpesvirus 8 lymphokine oncoprotein phosphatidylinositol 3 kinase protein kinase B protein serine threonine kinase signal peptide telomerase vasculotropin vasculotropin A apoptosis article association autocrine effect cell immortalization endothelium cell human human cell Human herpesvirus 8 priority journal protein expression protein function signal transduction telomere umbilical vein cell culture cell transformation genetics Kaposi sarcoma metabolism pathogenicity pathology phosphorylation physiology Retrovirus vascular endothelium virology Herpesviridae Oncovirinae Papovaviridae 1-Phosphatidylinositol 3-Kinase Apoptosis Cell Transformation, Neoplastic Cells, Cultured Endothelial Growth Factors Endothelium, Vascular Herpesvirus 8, Human Humans Intercellular Signaling Peptides and Proteins Lymphokines Phosphorylation Protein-Serine-Threonine Kinases Proto-Oncogene Proteins Proto-Oncogene Proteins c-akt Receptors, Chemokine Retroviridae Sarcoma, Kaposi Signal Transduction Telomerase Telomere Umbilical Veins Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-2 Vascular Endothelial Growth Factors Viral Proteins
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15356108_v3_n2_p131_Bais http://hdl.handle.net/20.500.12110/paper_15356108_v3_n2_p131_Bais
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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