Vasoactive intestinal peptide inhibits TNF-α-induced apoptotic events in acinar cells from nonobese diabetic mice submandibular glands

Introduction: The role of apoptotic secretory epithelium as a pro-inflammatory triggering factor of exocrine dysfunction is currently explored in Sjogren's syndrome patients and in the nonobese diabetic (NOD) mouse model. Vasoactive intestinal peptide (VIP) has anti-inflammatory effects in vari...

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Detalles Bibliográficos
Autores principales:	Calafat, Mario José, Larocca, Luciana, Roca, Valeria Inés, Hauk, Vanesa Cintia, Pregi, Nicolás, Nesse, Alcira Beatriz, Pérez Leirós, Claudia
Publicado:	2009
Materias:	amylase caspase 3 cyclic AMP dependent protein kinase nuclear protein protein Bax tumor necrosis factor alpha tumor necrosis factor alpha receptor tumor protein 53 induced nuclear protein 1 alpha unclassified drug vasoactive intestinal polypeptide vasoactive intestinal polypeptide receptor 1 acinar cell animal cell animal experiment animal model animal tissue apoptosis article controlled study enzyme activity enzyme substrate female mouse nonhuman nonobese diabetic mouse protein expression protein function protein protein interaction salivary gland disease salivation submandibular gland animal Bagg albino mouse disease model metabolism pathology physiology reverse transcription polymerase chain reaction signal transduction Sjoegren syndrome Western blotting Animals Apoptosis Blotting, Western Cyclic AMP-Dependent Protein Kinases Disease Models, Animal Female Mice Mice, Inbred BALB C Mice, Inbred NOD Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Sjogren's Syndrome Submandibular Gland Tumor Necrosis Factor-alpha Vasoactive Intestinal Peptide
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14786354_v11_n2_p_Calafat http://hdl.handle.net/20.500.12110/paper_14786354_v11_n2_p_Calafat
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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