6,19-carbon-bridged steroids. Synthesis of 6,19-methano-progesterone

6,19-Methanoprogesterone (4) was synthesized in nine steps from the readily available 3β,20β-diacetyloxy-5α-bromo-6,19,-oxidopregnane (5) in 14% overall yield. The additional carbon atom was introduced by reaction of a C-19 aldehyde with Ph3PCHOCH3 under salt free conditions and subsequent hydrolysi...

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Detalles Bibliográficos
Autores principales:	Joselevich, María, Ghini, Alberto Antonio, Burton, Gerardo
Publicado:	2003
Materias:	Addition reactions Aldehydes Atoms Calculations Carbon Conformations Derivatives Hydrolysis Molecular structure Synthesis (chemical) Diacetyloxybromooxidopregnane Lewis acid Methanoprogesterone Organic compounds 6,19 methanoprogesterone 6,19-methanoprogesterone drug derivative progesterone steroid article chemical model chemical structure synthesis Models, Chemical Molecular Structure Progesterone Steroids
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14770520_v1_n6_p939_Joselevich http://hdl.handle.net/20.500.12110/paper_14770520_v1_n6_p939_Joselevich
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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