Recognition-driven assembly of self-limiting supramolecular protein nanoparticles displaying enzymatic activity

We report the recognition-driven assembly of self-limiting protein nanoparticles displaying enzymatic activity. Solution self-assembly of concanavalin A lectin and glycoenzyme glucose oxidase leads to the spontaneous formation of biocolloids with well-defined dimensions, narrow size distribution and...

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Detalles Bibliográficos
Autores principales: Pallarola, Diego Andrés, Battaglini, Fernando
Publicado: 2015
Materias:
concanavalin A
glucose oxidase
lectin
mannose
nanoparticle
protein
enzyme
Article
chemical modification
controlled study
electrode
enzyme active site
enzyme activity
hydrodynamics
protein aggregation
protein assembly
protein interaction
static electricity
stoichiometry
Enzymes
Nanoparticles
Proteins
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13597345_v51_n79_p14754_Piccinini
http://hdl.handle.net/20.500.12110/paper_13597345_v51_n79_p14754_Piccinini
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:We report the recognition-driven assembly of self-limiting protein nanoparticles displaying enzymatic activity. Solution self-assembly of concanavalin A lectin and glycoenzyme glucose oxidase leads to the spontaneous formation of biocolloids with well-defined dimensions, narrow size distribution and remarkable stability. These biocolloids successfully recognize a glycosylated modified electrode retaining the enzyme activity. © The Royal Society of Chemistry 2015.

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