Methamphetamine blunts Ca2+ currents and excitatory synaptic transmission through D1/5 receptor-mediated mechanisms in the mouse medial prefrontal cortex

Psychostimulant addiction is associated with dysfunctions in frontal cortex. Previous data demonstrated that repeated exposure to methamphetamine (METH) can alter prefrontal cortex (PFC)-dependent functions. Here, we show that withdrawal from repetitive non-contingent METH administration (7 days, 1...

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Detalles Bibliográficos
Publicado:	2016
Materias:	Dopamine receptors glutamate methamphetamine prefrontal cortex voltage-gated calcium channels 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate AMPA receptor calcium channel N type calcium channel P type calcium channel Q type calcium channel T type cyclic nucleotide gated channel dopamine 1 receptor dopamine 5 receptor messenger RNA metabotropic receptor n methyl dextro aspartic acid receptor benzazepine derivative Cacna1b protein, mouse Cacna1g protein, mouse Cacna1h protein, mouse Cacna1i protein, mouse CACNA2D1 protein, mouse calcium calcium channel dopamine uptake inhibitor glutamate receptor ionotropic, AMPA 1 Gprin1 protein, mouse Hcn1 protein, mouse Hcn2 protein, mouse hyperpolarization activated cyclic nucleotide gated channel nerve protein potassium channel voltage-dependent calcium channel (P-Q type) animal experiment animal model animal tissue Article Cacna1a gene Cacna1b gene Cacna1g gene Cacna1h gene Cacna1i gene Cacna2d1 gene calcium current controlled study excitatory postsynaptic potential gene gene expression Gria1 gene Grin1 gene Hcn1 gene Hcn2 gene hyperpolarization in vitro study male medial prefrontal cortex methamphetamine dependence mouse nonhuman priority journal synaptic transmission animal antagonists and inhibitors drug effects genetics metabolism pyramidal nerve cell Animals Benzazepines Calcium Calcium Channels Calcium Channels, N-Type Calcium Channels, T-Type Dopamine Uptake Inhibitors Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels Male Methamphetamine Mice Nerve Tissue Proteins Potassium Channels Prefrontal Cortex Pyramidal Cells Receptors, AMPA Receptors, Dopamine D1 Receptors, Dopamine D5 Receptors, N-Methyl-D-Aspartate RNA, Messenger Synaptic Transmission
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13556215_v21_n3_p589_Gonzalez http://hdl.handle.net/20.500.12110/paper_13556215_v21_n3_p589_Gonzalez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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