Co-alteration of dopamine D2 receptor and muscarinic acetylcholine receptor binding in rat striatum after circling training
Circling training (CT) decreases muscarinic acetylcholine receptor (mAchR) binding in rat striatum. As cholinergic and dopaminergic systems interact strongly we evaluated the expression of D2-subtype dopamine receptor (DA D2) and mAchR together after CT. Animals trained from 30 to 37 days of age and...
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| Autores principales: | , , |
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1996
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09594965_v7_n15-17_p2491_Ibarra http://hdl.handle.net/20.500.12110/paper_09594965_v7_n15-17_p2491_Ibarra |
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| Sumario: | Circling training (CT) decreases muscarinic acetylcholine receptor (mAchR) binding in rat striatum. As cholinergic and dopaminergic systems interact strongly we evaluated the expression of D2-subtype dopamine receptor (DA D2) and mAchR together after CT. Animals trained from 30 to 37 days of age and sacrificed 2 months later showed an enduring drop in B(max) of 40% in DA D2 and 34% in mAchR. plotting the percentage of binding drop of both receptors for each animal showed that the reduction of one system correlates with the other (r2 = 0.71, p < 0.01; n = 8). Neither mAchR nor DA D2 were affected when training started at 20 or 60 days. We conclude that the presence of a period where CT exerts long term alterations during development involves both cholinergic and dopaminergic systems. |
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