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spelling paper:paper_08189641_v90_n4_p449_FernandezDoPorto2023-06-08T15:46:02Z CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis CD137 cytokines monocytes NK cells T cells tuberculosis CD137 antigen CD137 ligand gamma interferon tumor necrosis factor alpha adaptive immunity adult apoptosis article CD8+ T lymphocyte cell expansion cell proliferation cell survival clinical article controlled study cytokine production degranulation female human human cell human tissue immunoregulation innate immunity lung tuberculosis male monocyte Mycobacterium tuberculosis natural killer cell nonhuman protein expression protein protein interaction T lymphocyte upregulation 4-1BB Ligand Adaptive Immunity Antigens, CD137 Cells, Cultured Humans Immunity, Innate Killer Cells, Natural Mycobacterium tuberculosis T-Lymphocytes Tuberculosis Mycobacterium tuberculosis Protective immunity against Mycobacterium tuberculosis is primarily mediated by the interaction of antigen-specific T cells and antigen presenting cells, which often depends on the interplay of cytokines produced by these cells. Costimulatory signals represent a complex network of receptor-ligand interactions that qualitatively and quantitatively influence immune responses. Thus, here we investigated the function of CD137 and CD137L, molecules known to have a central role in immune regulation, during human tuberculosis (TB). We demonstrated that M. tuberculosis antigen stimulation increased both CD137 and CD137L expression on monocytes and NK cells from TB patients and healthy donors, but only up-regulated CD137 on T lymphocytes. Blockage of the CD137 pathway enhanced the levels of interferon (IFN)-γ and tumor necrosis factor (TNF)-α produced by monocytes and NK against M. tuberculosis. In contrast, CD137 blockage significantly decreased the specific degranulation of CD8 + T cells and the percentage of specific IFN-γ and TNF-α producing lymphocytes against the pathogen. Furthermore, inhibition of the CD137 pathway markedly increased T-cell apoptosis. Taken together, our results demonstrate that CD137:CD137L interactions regulate the innate and adaptive immune response of the host against M. tuberculosis. © 2012 Australasian Society for Immunology Inc. All rights reserved. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08189641_v90_n4_p449_FernandezDoPorto http://hdl.handle.net/20.500.12110/paper_08189641_v90_n4_p449_FernandezDoPorto
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic CD137
cytokines
monocytes
NK cells
T cells
tuberculosis
CD137 antigen
CD137 ligand
gamma interferon
tumor necrosis factor alpha
adaptive immunity
adult
apoptosis
article
CD8+ T lymphocyte
cell expansion
cell proliferation
cell survival
clinical article
controlled study
cytokine production
degranulation
female
human
human cell
human tissue
immunoregulation
innate immunity
lung tuberculosis
male
monocyte
Mycobacterium tuberculosis
natural killer cell
nonhuman
protein expression
protein protein interaction
T lymphocyte
upregulation
4-1BB Ligand
Adaptive Immunity
Antigens, CD137
Cells, Cultured
Humans
Immunity, Innate
Killer Cells, Natural
Mycobacterium tuberculosis
T-Lymphocytes
Tuberculosis
Mycobacterium tuberculosis
spellingShingle CD137
cytokines
monocytes
NK cells
T cells
tuberculosis
CD137 antigen
CD137 ligand
gamma interferon
tumor necrosis factor alpha
adaptive immunity
adult
apoptosis
article
CD8+ T lymphocyte
cell expansion
cell proliferation
cell survival
clinical article
controlled study
cytokine production
degranulation
female
human
human cell
human tissue
immunoregulation
innate immunity
lung tuberculosis
male
monocyte
Mycobacterium tuberculosis
natural killer cell
nonhuman
protein expression
protein protein interaction
T lymphocyte
upregulation
4-1BB Ligand
Adaptive Immunity
Antigens, CD137
Cells, Cultured
Humans
Immunity, Innate
Killer Cells, Natural
Mycobacterium tuberculosis
T-Lymphocytes
Tuberculosis
Mycobacterium tuberculosis
CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis
topic_facet CD137
cytokines
monocytes
NK cells
T cells
tuberculosis
CD137 antigen
CD137 ligand
gamma interferon
tumor necrosis factor alpha
adaptive immunity
adult
apoptosis
article
CD8+ T lymphocyte
cell expansion
cell proliferation
cell survival
clinical article
controlled study
cytokine production
degranulation
female
human
human cell
human tissue
immunoregulation
innate immunity
lung tuberculosis
male
monocyte
Mycobacterium tuberculosis
natural killer cell
nonhuman
protein expression
protein protein interaction
T lymphocyte
upregulation
4-1BB Ligand
Adaptive Immunity
Antigens, CD137
Cells, Cultured
Humans
Immunity, Innate
Killer Cells, Natural
Mycobacterium tuberculosis
T-Lymphocytes
Tuberculosis
Mycobacterium tuberculosis
description Protective immunity against Mycobacterium tuberculosis is primarily mediated by the interaction of antigen-specific T cells and antigen presenting cells, which often depends on the interplay of cytokines produced by these cells. Costimulatory signals represent a complex network of receptor-ligand interactions that qualitatively and quantitatively influence immune responses. Thus, here we investigated the function of CD137 and CD137L, molecules known to have a central role in immune regulation, during human tuberculosis (TB). We demonstrated that M. tuberculosis antigen stimulation increased both CD137 and CD137L expression on monocytes and NK cells from TB patients and healthy donors, but only up-regulated CD137 on T lymphocytes. Blockage of the CD137 pathway enhanced the levels of interferon (IFN)-γ and tumor necrosis factor (TNF)-α produced by monocytes and NK against M. tuberculosis. In contrast, CD137 blockage significantly decreased the specific degranulation of CD8 + T cells and the percentage of specific IFN-γ and TNF-α producing lymphocytes against the pathogen. Furthermore, inhibition of the CD137 pathway markedly increased T-cell apoptosis. Taken together, our results demonstrate that CD137:CD137L interactions regulate the innate and adaptive immune response of the host against M. tuberculosis. © 2012 Australasian Society for Immunology Inc. All rights reserved.
title CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis
title_short CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis
title_full CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis
title_fullStr CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis
title_full_unstemmed CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis
title_sort cd137 differentially regulates innate and adaptive immunity against mycobacterium tuberculosis
publishDate 2012
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08189641_v90_n4_p449_FernandezDoPorto
http://hdl.handle.net/20.500.12110/paper_08189641_v90_n4_p449_FernandezDoPorto
_version_ 1768543757009944576