Synthesis of C-5'-nor-dideoxycarbanucleosides structurally related to neplanocin C

Purine carbanucleosides built on a 6-oxabicyclo[3.1.0]hexane template were synthesized from readily available 2-cyclopentenone employing a Mitsunobu reaction to incorporate the base onto the carbocyclic ring. Both adenosine and guanosine analogues exhibited moderate antiviral activity.

Detalles Bibliográficos
Autores principales: Comin, María Julieta, Pujol, Carlos Alberto, Damonte, Elsa Beatriz, Rodríguez, Juan Bautista
Publicado: 1999
Materias:
aciclovir
adenosine derivative
guanosine derivative
purine nucleoside
animal cell
antiviral activity
article
controlled study
drug activity
drug structure
drug synthesis
Herpes simplex virus 1
Herpes simplex virus 2
human
human cell
Human cytomegalovirus
nonhuman
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07328311_v18_n10_p2219_Comin
http://hdl.handle.net/20.500.12110/paper_07328311_v18_n10_p2219_Comin
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Purine carbanucleosides built on a 6-oxabicyclo[3.1.0]hexane template were synthesized from readily available 2-cyclopentenone employing a Mitsunobu reaction to incorporate the base onto the carbocyclic ring. Both adenosine and guanosine analogues exhibited moderate antiviral activity.

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