Bacillus anthracis: A molecular look at a famous pathogen

Bacillus anthracis, a gram-positive rod belonging to the Bacillus cereus group, has an extremely monomorphic genome, and presents high structural and physiological similarity with B. cereus and Bacillus thuringiensis. In this work, the new molecular methods for the identification and typing of B. an...

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Autores principales:	Pettinari, María Julia, Cataldi, Angel Adrián
Publicado:	2011
Materias:	Anthrax Bacillus anthracis Genetic diversity Megaplasmids Molecular aspects Virulence factors adhesin bacillibactin bacterial antigen bacterium edema factor lipoprotein petrobactin protein MntA siderophore unclassified drug virulence factor article bacterial membrane bacterial virulence bacterium identification host pathogen interaction lethal gene nonhuman pathogenicity island plasmid species tandem repeat Animals Antigens, Bacterial Bacillus Bacterial Capsules Bacterial Toxins Bacterial Typing Techniques Base Sequence DNA, Bacterial Genomic Islands Humans Membrane Proteins Minisatellite Repeats Molecular Sequence Data Neoplasm Proteins Plasmids Polymorphism, Single Nucleotide Receptors, Cell Surface Sequence Alignment Sequence Homology, Nucleic Acid Virulence Zoonoses
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03257541_v43_n4_p294_Pavan http://hdl.handle.net/20.500.12110/paper_03257541_v43_n4_p294_Pavan
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_03257541_v43_n4_p294_Pavan
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spelling	paper:paper_03257541_v43_n4_p294_Pavan2023-06-08T15:32:55Z Bacillus anthracis: A molecular look at a famous pathogen Pettinari, María Julia Cataldi, Angel Adrián Anthrax Bacillus anthracis Genetic diversity Megaplasmids Molecular aspects Virulence factors adhesin bacillibactin bacterial antigen bacterium edema factor lipoprotein petrobactin protein MntA siderophore unclassified drug virulence factor article Bacillus anthracis bacterial membrane bacterial virulence bacterium identification host pathogen interaction lethal gene nonhuman pathogenicity island plasmid species tandem repeat Animals Anthrax Antigens, Bacterial Bacillus Bacillus anthracis Bacterial Capsules Bacterial Toxins Bacterial Typing Techniques Base Sequence DNA, Bacterial Genomic Islands Humans Membrane Proteins Minisatellite Repeats Molecular Sequence Data Neoplasm Proteins Plasmids Polymorphism, Single Nucleotide Receptors, Cell Surface Sequence Alignment Sequence Homology, Nucleic Acid Virulence Zoonoses Bacillus anthracis, a gram-positive rod belonging to the Bacillus cereus group, has an extremely monomorphic genome, and presents high structural and physiological similarity with B. cereus and Bacillus thuringiensis. In this work, the new molecular methods for the identification and typing of B. anthracis developed in the last years, based on variable number tandem repeats or on genetic differences detected through sequencing, are described. The molecular aspects of traditional virulence factors: capsule, protective antigen, lethal factor and edema factor are described in depth, together with virulence factors recently proposed, such as the siderophores petrobactin and bacillibactin, the S-layer adhesin and the MntA lipoprotein. It is detailed the molecular organization of megaplasmids pXO1 and pXO2, including the pathogenicity island of pXO1. The genetic skeleton of these plasmids has been observed in related species, and this could be attributed to lateral gene transfer. Finally, the two anthrax toxin protective antigen receptors, ANTXR1/TEM8 and ANTXR2/CMG2, essential for the interaction of the pathogen with the host, are presented. The molecular studies performed in recent years have greatly increased knowledge in different aspects of this microorganism and its relationship with the host, but at the same time they have raised new questions about this noted pathogen. Fil:Pettinari, M.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cataldi, A.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2011 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03257541_v43_n4_p294_Pavan http://hdl.handle.net/20.500.12110/paper_03257541_v43_n4_p294_Pavan
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Anthrax Bacillus anthracis Genetic diversity Megaplasmids Molecular aspects Virulence factors adhesin bacillibactin bacterial antigen bacterium edema factor lipoprotein petrobactin protein MntA siderophore unclassified drug virulence factor article Bacillus anthracis bacterial membrane bacterial virulence bacterium identification host pathogen interaction lethal gene nonhuman pathogenicity island plasmid species tandem repeat Animals Anthrax Antigens, Bacterial Bacillus Bacillus anthracis Bacterial Capsules Bacterial Toxins Bacterial Typing Techniques Base Sequence DNA, Bacterial Genomic Islands Humans Membrane Proteins Minisatellite Repeats Molecular Sequence Data Neoplasm Proteins Plasmids Polymorphism, Single Nucleotide Receptors, Cell Surface Sequence Alignment Sequence Homology, Nucleic Acid Virulence Zoonoses
spellingShingle	Anthrax Bacillus anthracis Genetic diversity Megaplasmids Molecular aspects Virulence factors adhesin bacillibactin bacterial antigen bacterium edema factor lipoprotein petrobactin protein MntA siderophore unclassified drug virulence factor article Bacillus anthracis bacterial membrane bacterial virulence bacterium identification host pathogen interaction lethal gene nonhuman pathogenicity island plasmid species tandem repeat Animals Anthrax Antigens, Bacterial Bacillus Bacillus anthracis Bacterial Capsules Bacterial Toxins Bacterial Typing Techniques Base Sequence DNA, Bacterial Genomic Islands Humans Membrane Proteins Minisatellite Repeats Molecular Sequence Data Neoplasm Proteins Plasmids Polymorphism, Single Nucleotide Receptors, Cell Surface Sequence Alignment Sequence Homology, Nucleic Acid Virulence Zoonoses Pettinari, María Julia Cataldi, Angel Adrián Bacillus anthracis: A molecular look at a famous pathogen
topic_facet	Anthrax Bacillus anthracis Genetic diversity Megaplasmids Molecular aspects Virulence factors adhesin bacillibactin bacterial antigen bacterium edema factor lipoprotein petrobactin protein MntA siderophore unclassified drug virulence factor article Bacillus anthracis bacterial membrane bacterial virulence bacterium identification host pathogen interaction lethal gene nonhuman pathogenicity island plasmid species tandem repeat Animals Anthrax Antigens, Bacterial Bacillus Bacillus anthracis Bacterial Capsules Bacterial Toxins Bacterial Typing Techniques Base Sequence DNA, Bacterial Genomic Islands Humans Membrane Proteins Minisatellite Repeats Molecular Sequence Data Neoplasm Proteins Plasmids Polymorphism, Single Nucleotide Receptors, Cell Surface Sequence Alignment Sequence Homology, Nucleic Acid Virulence Zoonoses
description	Bacillus anthracis, a gram-positive rod belonging to the Bacillus cereus group, has an extremely monomorphic genome, and presents high structural and physiological similarity with B. cereus and Bacillus thuringiensis. In this work, the new molecular methods for the identification and typing of B. anthracis developed in the last years, based on variable number tandem repeats or on genetic differences detected through sequencing, are described. The molecular aspects of traditional virulence factors: capsule, protective antigen, lethal factor and edema factor are described in depth, together with virulence factors recently proposed, such as the siderophores petrobactin and bacillibactin, the S-layer adhesin and the MntA lipoprotein. It is detailed the molecular organization of megaplasmids pXO1 and pXO2, including the pathogenicity island of pXO1. The genetic skeleton of these plasmids has been observed in related species, and this could be attributed to lateral gene transfer. Finally, the two anthrax toxin protective antigen receptors, ANTXR1/TEM8 and ANTXR2/CMG2, essential for the interaction of the pathogen with the host, are presented. The molecular studies performed in recent years have greatly increased knowledge in different aspects of this microorganism and its relationship with the host, but at the same time they have raised new questions about this noted pathogen.
author	Pettinari, María Julia Cataldi, Angel Adrián
author_facet	Pettinari, María Julia Cataldi, Angel Adrián
author_sort	Pettinari, María Julia
title	Bacillus anthracis: A molecular look at a famous pathogen
title_short	Bacillus anthracis: A molecular look at a famous pathogen
title_full	Bacillus anthracis: A molecular look at a famous pathogen
title_fullStr	Bacillus anthracis: A molecular look at a famous pathogen
title_full_unstemmed	Bacillus anthracis: A molecular look at a famous pathogen
title_sort	bacillus anthracis: a molecular look at a famous pathogen
publishDate	2011
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03257541_v43_n4_p294_Pavan http://hdl.handle.net/20.500.12110/paper_03257541_v43_n4_p294_Pavan
work_keys_str_mv	AT pettinarimariajulia bacillusanthracisamolecularlookatafamouspathogen AT cataldiangeladrian bacillusanthracisamolecularlookatafamouspathogen
_version_	1768543704055808000

Bacillus anthracis: A molecular look at a famous pathogen

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