Is fibrinogen determination by prothrombine time derived method confidant?
Elevated plasma fibrinogen (Fbg) levels have been shown, to be a risk factor for thrombotic events and cardiovascular disease. Currently, Fbg concentration is measured by Clauss and the prothrombine-time derived method. Despite of the derived method is simple and rapid, several studies have suggeste...
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| Autores principales: | , , , |
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| Publicado: |
2002
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v36_n3_p329_Lauricella http://hdl.handle.net/20.500.12110/paper_03252957_v36_n3_p329_Lauricella |
| Aporte de: |
| Sumario: | Elevated plasma fibrinogen (Fbg) levels have been shown, to be a risk factor for thrombotic events and cardiovascular disease. Currently, Fbg concentration is measured by Clauss and the prothrombine-time derived method. Despite of the derived method is simple and rapid, several studies have suggested that this technique would provide higher Fbg values than the real ones. In order to evaluate the accuracy of this method, the results were compared to those obtained by Clauss method (Bland-Altman procedure and Median test). Moreover, it was studied the heparine effect (0.2 to 0.6 UI/ml) on the Fbg levels determinated by prothrombine-time method (linear regression and Pearson correlation). The comparison between Fbg values obtained by Clauss and prothrombine-time derived methods, shows that results from both techniques are equivalent in the normal range. However, at Fbg values higher than 400 mg/dl another method, like Clauss, would be used. The results obtained by prothrombine-time derived method were not modified with heparinized samples in the therapeutic range. |
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