On the synthesis of prostaglandins E1,E2 and F2α by sow oviducts. Differential modulation of 1 and 2 series of prostaglandins by norepinephrine.
The present study was performed in order to evaluate whether norepinephrine (NE) can modulate the synthesis and release of 1 and 2 series of prostaglandins (PGs) by the isthmic region of pre-ovulatory sow oviducts and also to clarify whether the action of the neurotransmitter is mediated through alp...
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1985
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02621746_v17_n1_p61_Gimeno http://hdl.handle.net/20.500.12110/paper_02621746_v17_n1_p61_Gimeno |
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| Sumario: | The present study was performed in order to evaluate whether norepinephrine (NE) can modulate the synthesis and release of 1 and 2 series of prostaglandins (PGs) by the isthmic region of pre-ovulatory sow oviducts and also to clarify whether the action of the neurotransmitter is mediated through alpha, through beta or through both types of tissue adrenoreceptors. NE, at a concentration of 1 ug/ml, depressed significantly (P < 0.05) the basal output of PGE1 and enhanced (P< 0.01) the release of PGE2 but, did not modify, the output of "PGF2α-like material". Propranolol (10-7M) failed to alter the basal output of "PGE1, PGE2 or PGF2α-like material". In the presence of this beta-adrenoreceptor blocker, the depression induced by NE on PGE1 output, was abolished; its stimulatory influence on the release of PGE2, was eliminated and no effect was detected regarding PGF2α . On the other hand, phentolamine (10-6M) did not alter the basal output of PGE1, PGE2 or PGF2α -like material" and also failed to modify the depression induced by NE an PGE1 release. However, this alpha adrenoceptor blacker completely inhibited the stimulatory action of NE on the output of PGE2 into the incubating medium. The foregoing results document opposite actions of NE on PGE1 and PGE2 outputs from the isthmic region of proestrous sow oviducts and suggest the involvement of beta-adrenoreceptors in both disparate influences. The activation of alpha adrenoreceptors also appears associated with the enhancing effect of the agonist on the release of PGE2. The possible physiological significance of these findings is discussed in terms of the function of the isthmic region as an "adrenergic sphincter" able to influence ovum transport around the moment of ovulation. © 1985. |
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