Lipoxygenase inhibitors alter aggregation and adhesiveness of human blood platelets from aspirin-treated patients
The influences of arachidonic acid (AA) and of inhibitors of lipoxygenases (eicosetetraynoic acid-ETYA- and nordihydrogusiaretic acid -NDGA-) on platelet aggregation evoked by collagen or adenosinediphosphate (ADP) as well as platelet adhesiveness to collagen f platelet-rich-plasma (PRP) from aspiri...
Guardado en:
| Publicado: |
1983
|
|---|---|
| Materias: | |
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02621746_v11_n1_p109_Gimeno http://hdl.handle.net/20.500.12110/paper_02621746_v11_n1_p109_Gimeno |
| Aporte de: |
| Sumario: | The influences of arachidonic acid (AA) and of inhibitors of lipoxygenases (eicosetetraynoic acid-ETYA- and nordihydrogusiaretic acid -NDGA-) on platelet aggregation evoked by collagen or adenosinediphosphate (ADP) as well as platelet adhesiveness to collagen f platelet-rich-plasma (PRP) from aspirin-treated patients were explored. ETYA or NDGA (10-8 and 10-7 M) clearly diminished the per cent aggregation evoked by collagen or ADP and delayed its onset. On the other hand AA (0.2 mM) enhanced the aggregation and shortened the leg phase evoked by collagen at 1.2 and 2.6 ug/ml, but not at 5.2 ug/ml. Platelet-collagen adhesion of PRP was significantly reduced by ETYA or NDGA (10-7 M) and augmented by AA (2 mM). The results strongly suggest that lipoxygenese products of arachidonate metabolism play an important role in promoting the mechanisms) underlying human platelet aggregation and adhesiveness. © 1983. |
|---|