Participation of the phosphatidylinositol 3-kinase/Akt pathway in Junín virus replication in vitro

In this paper we demonstrate that infection of cell cultures with the arenavirus Junín (JUNV), agent of the argentine haemorrhagic fever, leads to the activation of PI3K/Akt signalling pathway. Phosphorylation of Akt occurs early during JUNV infection of Vero cells and is blocked by the PI3K inhibit...

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Detalles Bibliográficos
Autores principales: Linero, Florencia N., Scolaro, Luis Alberto
Publicado: 2009
Materias:
Akt
Argentine hemorrhagic fever
Junín virus
Ly294002
Phosphatidylinositol 3-kinase
cell receptor
phosphatidylinositol 3 kinase
protein kinase B
transferrin receptor
animal cell
article
cell surface
controlled study
enzyme activation
enzyme inhibition
enzyme phosphorylation
human
human cell
in vitro study
Junin virus
nonhuman
persistent virus infection
priority journal
protein expression
protein synthesis
ultraviolet radiation
Vero cell
virus activation
virus cell interaction
virus entry
virus infection
virus replication
1-Phosphatidylinositol 3-Kinase
Animals
Cercopithecus aethiops
Chromones
Cricetinae
Enzyme Inhibitors
Hemorrhagic Fever, American
Host-Pathogen Interactions
Humans
Morpholines
Phosphorylation
Proto-Oncogene Proteins c-akt
Signal Transduction
Vero Cells
Virus Internalization
Virus Replication
Arenavirus
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01681702_v145_n1_p166_Linero
http://hdl.handle.net/20.500.12110/paper_01681702_v145_n1_p166_Linero
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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