Glutamatergic system: Another target for the action of porphyrinogenic agents

The N-methyl-diethyl-aspartate (NMDA) receptor has been reported to play an important role in several acute and chronic neuropathologic syndromes. 5-aminolevulinic acid (ALA) accumulates in acute porphyrias due to a deficiency in the heme biosynthetic pathway. Considering that glutamate uptake inhib...

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Autores principales:	Lavandera, Jimena Verónica, Fossati, Mariana, Azcurra, Julio Marcos, Batlle, Alcira María del Carmen, Buzaleh, Ana María
Publicado:	2009
Materias:	Glutamatergic system N-methyl-diethyl-aspartate Porphyric neuropathy Porphyrinogenic agents allylisopropylacetamide aminolevulinic acid glutamic acid isoflurane n methyl dextro aspartic acid receptor animal experiment animal model animal tissue article binding affinity brain cortex cerebellum controlled study drug effect drug mechanism male mouse neuropathy nonhuman porphyria Aminolevulinic Acid Animals Barbital Cerebellum Cerebral Cortex Enflurane Ethanol Griseofulvin Isoflurane Male Mice Porphyrinogens Receptors, N-Methyl-D-Aspartate Mus
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01455680_v55_n1_p23_Lavandera http://hdl.handle.net/20.500.12110/paper_01455680_v55_n1_p23_Lavandera
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_01455680_v55_n1_p23_Lavandera
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spelling	paper:paper_01455680_v55_n1_p23_Lavandera2023-06-08T15:12:26Z Glutamatergic system: Another target for the action of porphyrinogenic agents Lavandera, Jimena Verónica Fossati, Mariana Azcurra, Julio Marcos Batlle, Alcira María del Carmen Buzaleh, Ana María Glutamatergic system N-methyl-diethyl-aspartate Porphyric neuropathy Porphyrinogenic agents allylisopropylacetamide aminolevulinic acid glutamic acid isoflurane n methyl dextro aspartic acid receptor animal experiment animal model animal tissue article binding affinity brain cortex cerebellum controlled study drug effect drug mechanism male mouse neuropathy nonhuman porphyria Aminolevulinic Acid Animals Barbital Cerebellum Cerebral Cortex Enflurane Ethanol Griseofulvin Isoflurane Male Mice Porphyrinogens Receptors, N-Methyl-D-Aspartate Mus The N-methyl-diethyl-aspartate (NMDA) receptor has been reported to play an important role in several acute and chronic neuropathologic syndromes. 5-aminolevulinic acid (ALA) accumulates in acute porphyrias due to a deficiency in the heme biosynthetic pathway. Considering that glutamate uptake inhibition caused by ALA could be one of the reasons conducing to porphyric neuropathy, it was of interest to evaluate the effect of porphyrinogenic agents on NMDA glutamatergic system. To this end receptor levels and apparent affinity (Kd) were analyzed in mice brain cortex and cerebellum. NMDA levels were diminished after chronic Isoflurane anaesthesia in brain cortex. In cerebellum, a diminution was observed after acute Enflurane and Isoflurane and allylisopropylacetamide, while ethanol administration showed a significant increase. ALA administration diminished NMDA levels only in cerebellum. Affinity constant was only reduced in brain cortex after chronic Isoflurane treatment. In conclusion, glutamatergic system appears to be involved in the action of some of the porphyrinogenic drugs studied mainly in cerebellum. Receptors regulation should therefore be considered an important mechanism in the cellular response to specific drugs, with the aim of designing new therapies and elucidating the mechanisms leading to porphyric neuropathy and acute attack triggering. Copyright © 2009 C.M.B. Edition. Fil:Lavandera, J.V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Fossati, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Azcurra, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Batlle, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Buzaleh, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2009 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01455680_v55_n1_p23_Lavandera http://hdl.handle.net/20.500.12110/paper_01455680_v55_n1_p23_Lavandera
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Glutamatergic system N-methyl-diethyl-aspartate Porphyric neuropathy Porphyrinogenic agents allylisopropylacetamide aminolevulinic acid glutamic acid isoflurane n methyl dextro aspartic acid receptor animal experiment animal model animal tissue article binding affinity brain cortex cerebellum controlled study drug effect drug mechanism male mouse neuropathy nonhuman porphyria Aminolevulinic Acid Animals Barbital Cerebellum Cerebral Cortex Enflurane Ethanol Griseofulvin Isoflurane Male Mice Porphyrinogens Receptors, N-Methyl-D-Aspartate Mus
spellingShingle	Glutamatergic system N-methyl-diethyl-aspartate Porphyric neuropathy Porphyrinogenic agents allylisopropylacetamide aminolevulinic acid glutamic acid isoflurane n methyl dextro aspartic acid receptor animal experiment animal model animal tissue article binding affinity brain cortex cerebellum controlled study drug effect drug mechanism male mouse neuropathy nonhuman porphyria Aminolevulinic Acid Animals Barbital Cerebellum Cerebral Cortex Enflurane Ethanol Griseofulvin Isoflurane Male Mice Porphyrinogens Receptors, N-Methyl-D-Aspartate Mus Lavandera, Jimena Verónica Fossati, Mariana Azcurra, Julio Marcos Batlle, Alcira María del Carmen Buzaleh, Ana María Glutamatergic system: Another target for the action of porphyrinogenic agents
topic_facet	Glutamatergic system N-methyl-diethyl-aspartate Porphyric neuropathy Porphyrinogenic agents allylisopropylacetamide aminolevulinic acid glutamic acid isoflurane n methyl dextro aspartic acid receptor animal experiment animal model animal tissue article binding affinity brain cortex cerebellum controlled study drug effect drug mechanism male mouse neuropathy nonhuman porphyria Aminolevulinic Acid Animals Barbital Cerebellum Cerebral Cortex Enflurane Ethanol Griseofulvin Isoflurane Male Mice Porphyrinogens Receptors, N-Methyl-D-Aspartate Mus
description	The N-methyl-diethyl-aspartate (NMDA) receptor has been reported to play an important role in several acute and chronic neuropathologic syndromes. 5-aminolevulinic acid (ALA) accumulates in acute porphyrias due to a deficiency in the heme biosynthetic pathway. Considering that glutamate uptake inhibition caused by ALA could be one of the reasons conducing to porphyric neuropathy, it was of interest to evaluate the effect of porphyrinogenic agents on NMDA glutamatergic system. To this end receptor levels and apparent affinity (Kd) were analyzed in mice brain cortex and cerebellum. NMDA levels were diminished after chronic Isoflurane anaesthesia in brain cortex. In cerebellum, a diminution was observed after acute Enflurane and Isoflurane and allylisopropylacetamide, while ethanol administration showed a significant increase. ALA administration diminished NMDA levels only in cerebellum. Affinity constant was only reduced in brain cortex after chronic Isoflurane treatment. In conclusion, glutamatergic system appears to be involved in the action of some of the porphyrinogenic drugs studied mainly in cerebellum. Receptors regulation should therefore be considered an important mechanism in the cellular response to specific drugs, with the aim of designing new therapies and elucidating the mechanisms leading to porphyric neuropathy and acute attack triggering. Copyright © 2009 C.M.B. Edition.
author	Lavandera, Jimena Verónica Fossati, Mariana Azcurra, Julio Marcos Batlle, Alcira María del Carmen Buzaleh, Ana María
author_facet	Lavandera, Jimena Verónica Fossati, Mariana Azcurra, Julio Marcos Batlle, Alcira María del Carmen Buzaleh, Ana María
author_sort	Lavandera, Jimena Verónica
title	Glutamatergic system: Another target for the action of porphyrinogenic agents
title_short	Glutamatergic system: Another target for the action of porphyrinogenic agents
title_full	Glutamatergic system: Another target for the action of porphyrinogenic agents
title_fullStr	Glutamatergic system: Another target for the action of porphyrinogenic agents
title_full_unstemmed	Glutamatergic system: Another target for the action of porphyrinogenic agents
title_sort	glutamatergic system: another target for the action of porphyrinogenic agents
publishDate	2009
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01455680_v55_n1_p23_Lavandera http://hdl.handle.net/20.500.12110/paper_01455680_v55_n1_p23_Lavandera
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Glutamatergic system: Another target for the action of porphyrinogenic agents

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