Two related forms of memory in the crab Chasmagnathus are differentially affected by NMDA receptor antagonists

A visual danger stimulus (VDS) elicits an escape response in the crab Chasmagnathus that declines after a few iterative presentations. Long-lasting retention of such decrement, termed context-signal memory (CSM), is mediated by an association between danger stimulus and environmental cues, cyclohexi...

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Publicado: 2002
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Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00913057_v72_n1-2_p251_Troncoso
http://hdl.handle.net/20.500.12110/paper_00913057_v72_n1-2_p251_Troncoso
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spelling paper:paper_00913057_v72_n1-2_p251_Troncoso2023-06-08T15:08:05Z Two related forms of memory in the crab Chasmagnathus are differentially affected by NMDA receptor antagonists AP5: MK-801 Crab Crustacea Learning Memory NMDA 2 amino 5 phosphonovaleric acid angiotensin cyclic AMP dependent protein kinase cycloheximide dizocilpine immunoglobulin enhancer binding protein n methyl dextro aspartic acid receptor n methyl dextro aspartic acid receptor blocking agent amino acid receptor blocking agent n methyl dextro aspartic acid receptor amnesia article associative memory controlled study crab Crustacea dose response drug effect environment enzyme activity male memory memory consolidation nonhuman priority journal stimulus training animal Brachyura comparative study drug antagonism physiology Chasmagnathus Crustacea Decapoda (Crustacea) Invertebrata Vertebrata Animals Brachyura Excitatory Amino Acid Antagonists Male Memory Receptors, N-Methyl-D-Aspartate A visual danger stimulus (VDS) elicits an escape response in the crab Chasmagnathus that declines after a few iterative presentations. Long-lasting retention of such decrement, termed context-signal memory (CSM), is mediated by an association between danger stimulus and environmental cues, cycloheximide sensitive, correlated with PKA activity and NFκ-B activation, positively modulated by angiotensins, and selectively regulated by a muscarinic-cholinergic mechanism. The present research was aimed at studying the possible involvement of NMDA-like receptors in CSM, given the role attributed to these receptors in vertebrate memory and their occurrence in invertebrates including crustaceans. Vertebrate antagonists (±)-2-amino-5-phosphonopentanoic acid (AP5) and (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801) were used. Memory retention impairment was shown with MK-801 10-3 M (1 μg/g) injected immediately before training or after training, or delayed 1 or 4 h, but not 6 h, posttraining. An AP5 10-3 M dose (0.6 μg/g) impairs retention when given before but not after training. Neither antagonist produced retrieval deficit. A memory process similar to CSM but nonassociative in nature and induced by massed training (termed signal memory, SM), proved entirely insensitive to AP5 or MK-801, confirming the view that distinct mechanisms subserve these different types of memory in the crab. © 2002 Elsevier Science Inc. All rights reserved. 2002 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00913057_v72_n1-2_p251_Troncoso http://hdl.handle.net/20.500.12110/paper_00913057_v72_n1-2_p251_Troncoso
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic AP5: MK-801
Crab
Crustacea
Learning
Memory
NMDA
2 amino 5 phosphonovaleric acid
angiotensin
cyclic AMP dependent protein kinase
cycloheximide
dizocilpine
immunoglobulin enhancer binding protein
n methyl dextro aspartic acid receptor
n methyl dextro aspartic acid receptor blocking agent
amino acid receptor blocking agent
n methyl dextro aspartic acid receptor
amnesia
article
associative memory
controlled study
crab
Crustacea
dose response
drug effect
environment
enzyme activity
male
memory
memory consolidation
nonhuman
priority journal
stimulus
training
animal
Brachyura
comparative study
drug antagonism
physiology
Chasmagnathus
Crustacea
Decapoda (Crustacea)
Invertebrata
Vertebrata
Animals
Brachyura
Excitatory Amino Acid Antagonists
Male
Memory
Receptors, N-Methyl-D-Aspartate
spellingShingle AP5: MK-801
Crab
Crustacea
Learning
Memory
NMDA
2 amino 5 phosphonovaleric acid
angiotensin
cyclic AMP dependent protein kinase
cycloheximide
dizocilpine
immunoglobulin enhancer binding protein
n methyl dextro aspartic acid receptor
n methyl dextro aspartic acid receptor blocking agent
amino acid receptor blocking agent
n methyl dextro aspartic acid receptor
amnesia
article
associative memory
controlled study
crab
Crustacea
dose response
drug effect
environment
enzyme activity
male
memory
memory consolidation
nonhuman
priority journal
stimulus
training
animal
Brachyura
comparative study
drug antagonism
physiology
Chasmagnathus
Crustacea
Decapoda (Crustacea)
Invertebrata
Vertebrata
Animals
Brachyura
Excitatory Amino Acid Antagonists
Male
Memory
Receptors, N-Methyl-D-Aspartate
Two related forms of memory in the crab Chasmagnathus are differentially affected by NMDA receptor antagonists
topic_facet AP5: MK-801
Crab
Crustacea
Learning
Memory
NMDA
2 amino 5 phosphonovaleric acid
angiotensin
cyclic AMP dependent protein kinase
cycloheximide
dizocilpine
immunoglobulin enhancer binding protein
n methyl dextro aspartic acid receptor
n methyl dextro aspartic acid receptor blocking agent
amino acid receptor blocking agent
n methyl dextro aspartic acid receptor
amnesia
article
associative memory
controlled study
crab
Crustacea
dose response
drug effect
environment
enzyme activity
male
memory
memory consolidation
nonhuman
priority journal
stimulus
training
animal
Brachyura
comparative study
drug antagonism
physiology
Chasmagnathus
Crustacea
Decapoda (Crustacea)
Invertebrata
Vertebrata
Animals
Brachyura
Excitatory Amino Acid Antagonists
Male
Memory
Receptors, N-Methyl-D-Aspartate
description A visual danger stimulus (VDS) elicits an escape response in the crab Chasmagnathus that declines after a few iterative presentations. Long-lasting retention of such decrement, termed context-signal memory (CSM), is mediated by an association between danger stimulus and environmental cues, cycloheximide sensitive, correlated with PKA activity and NFκ-B activation, positively modulated by angiotensins, and selectively regulated by a muscarinic-cholinergic mechanism. The present research was aimed at studying the possible involvement of NMDA-like receptors in CSM, given the role attributed to these receptors in vertebrate memory and their occurrence in invertebrates including crustaceans. Vertebrate antagonists (±)-2-amino-5-phosphonopentanoic acid (AP5) and (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801) were used. Memory retention impairment was shown with MK-801 10-3 M (1 μg/g) injected immediately before training or after training, or delayed 1 or 4 h, but not 6 h, posttraining. An AP5 10-3 M dose (0.6 μg/g) impairs retention when given before but not after training. Neither antagonist produced retrieval deficit. A memory process similar to CSM but nonassociative in nature and induced by massed training (termed signal memory, SM), proved entirely insensitive to AP5 or MK-801, confirming the view that distinct mechanisms subserve these different types of memory in the crab. © 2002 Elsevier Science Inc. All rights reserved.
title Two related forms of memory in the crab Chasmagnathus are differentially affected by NMDA receptor antagonists
title_short Two related forms of memory in the crab Chasmagnathus are differentially affected by NMDA receptor antagonists
title_full Two related forms of memory in the crab Chasmagnathus are differentially affected by NMDA receptor antagonists
title_fullStr Two related forms of memory in the crab Chasmagnathus are differentially affected by NMDA receptor antagonists
title_full_unstemmed Two related forms of memory in the crab Chasmagnathus are differentially affected by NMDA receptor antagonists
title_sort two related forms of memory in the crab chasmagnathus are differentially affected by nmda receptor antagonists
publishDate 2002
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00913057_v72_n1-2_p251_Troncoso
http://hdl.handle.net/20.500.12110/paper_00913057_v72_n1-2_p251_Troncoso
_version_ 1768542167970611200