Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease

We investigated the molecular basis of the activity of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the etiological agent of Chagas' disease. We found that growth inhibition of T. cruzi epimastigotes induced by this compound was associated with a reduction in the content...

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Guardado en:
Detalles Bibliográficos
Autor principal: Rodríguez, Juan Bautista
Publicado: 2003
Materias:
4 phenoxyphenoxyethyl thiocyanate
antiprotozoal agent
squalene synthase
sterol
unclassified drug
wc 9
antiprotozoal activity
article
Chagas disease
controlled study
drug activity
drug mechanism
epimastigote
growth inhibition
nonhuman
priority journal
sterol synthesis
Trypanosoma cruzi
Alkyl and Aryl Transferases
Animals
Dose-Response Relationship, Drug
Ergosterol
Farnesyl-Diphosphate Farnesyltransferase
Geranyltranstransferase
Humans
Microbial Sensitivity Tests
Phenyl Ethers
Thiocyanates
Trypanocidal Agents
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00664804_v47_n6_p2047_Urbina
http://hdl.handle.net/20.500.12110/paper_00664804_v47_n6_p2047_Urbina
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:We investigated the molecular basis of the activity of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the etiological agent of Chagas' disease. We found that growth inhibition of T. cruzi epimastigotes induced by this compound was associated with a reduction in the content of the parasite's endogenous sterols due to a specific blockade of their de novo synthesis at the level of squalene synthase.

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