Chemoenzymatic synthesis of new derivatives of glycyrrhetinic acid with antiviral activity. Molecular docking study

We present an efficient approach to the synthesis of a series of glycyrrhetinic acid derivatives. Six derivatives, five of them new compounds, were obtained through chemoenzymatic reactions in very good to excellent yield. In order to find the optimal reaction conditions, the influence of various pa...

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Detalles Bibliográficos
Publicado:	2018
Materias:	Antivirals Glycyrrhetinic acid Lipase-catalyzed Molecular modeling 3 acetylglycyrrhetinic acid glycyrrhetinic acid derivative n (3 acetylglycyrrhetinoyl) 1 amino 2 propanol n (3 acetylglycyrrhetinoyl) 2 amino 1 propanol n (3 acetylglycyrrhetinoyl) 4 hydroxy 1 butanol n (3 acetylglycyrrhetinoyl)butanolamine n (3 acetylglycyrrhetinoyl)ethanolamine solvent triacylglycerol lipase unclassified drug aciclovir antivirus agent glycyrrhetinic acid Lipozyme acetylation animal cell antiviral activity Article catalysis controlled study drug synthesis enzyme substrate enzyme synthesis Human alphaherpesvirus 1 molecular docking molecular model nonhuman priority journal Rhizomucor miehei temperature sensitivity biocatalysis Candida Carica chemical structure chemistry dose response drug effect enzymology Eurotiales metabolism microbial sensitivity test Rhizomucor Rhizopus structure activity relation Acyclovir Antiviral Agents Biocatalysis Dose-Response Relationship, Drug Glycyrrhetinic Acid Herpesvirus 1, Human Lipase Microbial Sensitivity Tests Molecular Docking Simulation Molecular Structure Structure-Activity Relationship
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00452068_v78_n_p210_Zigolo http://hdl.handle.net/20.500.12110/paper_00452068_v78_n_p210_Zigolo
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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