Synthesis and acetylcholinesterase inhibitory activity of 2β,3α-disulfoxy-5α-cholestan-6-one

Disodium 2β,3α-dihydroxy-5α-cholestan-6-one disulfate (8) has been synthesized using cholesterol (1) as starting material. Sulfation was performed using trimethylamine-sulfur trioxide complex in dimethylformamide as the sulfating agent. The acetylcholinesterase inhibitory activity of compound 8 was...

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Guardado en:
Detalles Bibliográficos
Autor principal: Maier, Marta Silvia
Publicado: 2011
Materias:
Acetylcholinesterase activity
Sulfated steroids
Synthesis
2 beta,3 alpha dihydroxy 5 alpha cholestane disulfate
acetylcholinesterase
cholesterol
cholesterol mesylate
cholinesterase inhibitor
disodium 2 beta,3 alpha dihydroxy 5 alpha cholestan 6 one disulfate
n,n dimethylformamide
oxide
sulfur trioxide
trimethylamine
unclassified drug
article
drug activity
drug sulfation
drug synthesis
enzyme activity
enzyme inhibition
IC 50
in vitro study
Acetylcholinesterase
Enzyme Activation
Kinetics
Magnetic Resonance Spectroscopy
Steroids
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0039128X_v76_n10-11_p1160_Richmond
http://hdl.handle.net/20.500.12110/paper_0039128X_v76_n10-11_p1160_Richmond
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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