C(16)-C(22) oxygen-bridged analogues of ceDAF-12 and LXR ligands

The DAF-12 receptor in nematodes and the Liver X Receptor (LXR) in mammals are structurally related transcription factors that play key roles in determining the life span of the organism. Both types of receptors are activated by oxysterols, cholesterol metabolites with oxidized side chains. Restrict...

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Detalles Bibliográficos
Autores principales:	Dansey, Maria Virginia, Pecci, Adali, Veleiro, Adriana Silvia, Burton, Gerardo
Publicado:	2016
Materias:	DAF-12 receptor Dafachronic acid Liver X Receptor Oxocarbenium reduction Oxysterols 26 hydroxycholesterol bacterial protein cell nucleus receptor DAF 12 receptor DAF 12 receptor agonist diosgenin hormone receptor stimulating agent liver X receptor liver X receptor agonist unclassified drug cholestane derivative cholesterol derivative dafachronic acid oxysterol animal cell Article controlled study desilylation DNA binding heteronuclear single quantum coherence human human cell isomerization ligand binding mass spectrometry nonhuman nuclear magnetic resonance oxidation promoter region protein conformation reporter gene stereochemistry stereoisomerism transactivation transactivation assay agonists animal cell line chemical structure chemistry hamster HEK293 cell line metabolism nuclear magnetic resonance spectroscopy Animals Cell Line Cholestenes Cricetinae HEK293 Cells Humans Hydroxycholesterols Liver X Receptors Magnetic Resonance Spectroscopy Molecular Structure
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0039128X_v112_n_p109_DelFueyo http://hdl.handle.net/20.500.12110/paper_0039128X_v112_n_p109_DelFueyo
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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