Kinetics, subcellular localization, and contribution to parasite virulence of a Trypanosoma cruzi hybrid type A heme peroxidase (TcAPx-CcP)

The Trypanosoma cruzi ascorbate peroxidase is, by sequence analysis, a hybrid type A member of class I heme peroxidases [TcAPx-cytochrome c peroxidase (CcP)], suggesting both ascorbate (Asc) and cytochrome c (Cc) peroxidase activity. Here, we show that the enzyme reacts fast with H2O2 (k = 2.9 × 107...

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Detalles Bibliográficos
Autor principal:	Estrin, Dario Ariel
Publicado:	2017
Materias:	Heme peroxidase Kinetics Oxidants Trypanosoma cruzi Virulence ascorbate peroxidase cytochrome c peroxidase heme hydrogen peroxide phenylalanine cytochrome c peroxidase tryptophan absorption spectroscopy amastigote animal cell animal experiment Article cell kinetics cell membrane cellular distribution controlled study electron spin resonance electron transport enzyme activity enzyme mechanism enzyme substrate host parasite interaction mass spectrometry mitochondrial membrane molecular dynamics mouse nonhuman parasite virulence priority journal protein expression spin trapping animal Bagg albino mouse C57BL mouse Chagas disease female kinetics male metabolism oxidation reduction reaction parasite parasitology pathogenicity physiology procedures site directed mutagenesis virulence Animals Chagas Disease Cytochrome c Group Electron Spin Resonance Spectroscopy Electron Transport Female Heme Hydrogen Peroxide Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mutagenesis, Site-Directed Oxidation-Reduction Parasites Peroxidase Phenylalanine Tryptophan
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00278424_v114_n8_pE1326_Hugo http://hdl.handle.net/20.500.12110/paper_00278424_v114_n8_pE1326_Hugo
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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