Different enzymatic activities recruitment by specific domains of TIF2 are involved in NF-κB transactivation

We have previously shown that nuclear receptor coactivator overexpression significantly enhanced NF-κB activity in a dose response manner. We studied the mechanism by which TIF2 regulates NF-κB activity. We determined that: 1) the p38 specific inhibitor reduces 50% NF-κB transcriptional activity, ev...

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Detalles Bibliográficos
Autores principales: Nojek, Ignacio Martín, Coló, Georgina Pamela, Rubio, María Fernanda, Franco, Diana Lorena, Costas, Mónica Alejandra
Publicado: 2004
Materias:
MAPK
NF-κB
Nuclear receptor coactivators
TIF2
cell protein
I kappa B
immunoglobulin enhancer binding protein
mitogen activated protein kinase
nuclear receptor coactivator 2
synaptophysin
transcription factor RelA
tumor necrosis factor alpha
mitogen activated protein kinase p38
NCOA2 protein, human
transcription factor
article
dose response
enzyme activity
gene overexpression
human
human cell
protein binding
protein determination
protein expression
protein interaction
transactivation
transcription regulation
cell nucleus
cytoplasm
drug antagonism
enzyme activation
metabolism
phosphorylation
physiology
Cell Nucleus
Cytoplasm
Enzyme Activation
Humans
NF-kappa B
Nuclear Receptor Coactivator 2
p38 Mitogen-Activated Protein Kinases
Phosphorylation
Trans-Activation (Genetics)
Transcription Factors
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00257680_v64_n2_p135_Nojek
http://hdl.handle.net/20.500.12110/paper_00257680_v64_n2_p135_Nojek
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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